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Induced precipitation of calcium-oxalate crystals and its prevention in laboratory animals

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Abstract

Induced precipitation of Ca-oxalate crystals and the possibility of its prevention were studied in dogs. In the first phase of the experiments precipitation of Ca-oxalate crystals in canine renal tubules was induced by intraperitoneal administration of Na-glyoxylate. Preventive medication (lipoic acid, vitamin B1, Milurit), applied in the second phase, resulted in a significant depression of induced precipitation. The successful experiments serve as a basis for clinical research aimed at a preventive medication of recurrent Ca-oxalate stone formation.

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Authors and Affiliations

  1. Department of Urology, University Medical School, Pécs, Hungary

    F. Götz, L. Gimes, J. Hübler, Gy. Temes & D. Frang

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  1. F. Götz
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  2. L. Gimes
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  3. J. Hübler
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  4. Gy. Temes
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  5. D. Frang
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Götz, F., Gimes, L., Hübler, J. et al. Induced precipitation of calcium-oxalate crystals and its prevention in laboratory animals. International Urology and Nephrology 18, 363–368 (1986). https://doi.org/10.1007/BF02084105

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  • DOI: https://doi.org/10.1007/BF02084105

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