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Kinetic versus thermodynamic factors in calcium renal lithiasis

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Abstract

Calcium renal lithiasis formation depends on the balance between thermodynamic (supersaturation) and kinetic (inhibitors, nucleants)factors. In this paper, the importance of both groups was evaluated using(a) the complete urine analysis data obtained from 32 healthy volunteers and 141 active stone-formers, and (b) a comprehensive computer model to calculate the supersaturation values of calcium oxalate monohydrate,hydroxyapatite and brushite in each urine sample. The results of this evaluation were used to assess the possible effectiveness of a given pharmacological treatment.

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Authors and Affiliations

  1. Laboratory of Renal Lithiasis Research, University of Illes Balears, Palma de Mallorca, Spain

    Felix Grases & Antonia Costa-Bauzá

  2. Department of Physical Chemistry, University of Leoben, Leoben, Austria

    Erich Königsberger & Lan-Chi Königsberger

Authors
  1. Felix Grases
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  2. Antonia Costa-Bauzá
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  3. Erich Königsberger
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  4. Lan-Chi Königsberger
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Grases, F., Costa-Bauzá, A., Königsberger, E. et al. Kinetic versus thermodynamic factors in calcium renal lithiasis. Int Urol Nephrol 32, 19–27 (2000). https://doi.org/10.1023/A:1007105328211

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  • DOI: https://doi.org/10.1023/A:1007105328211

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