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Attenuation of endothelium-dependent relaxation in mesenteric artery during noise-induced hypertension

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  • Published:
Journal of Biomedical Science

Abstract

The present study was designed to determine whether there is a causal relationship between noise-induced hypertension and changes of endothelial function. Rats were exposed to noise stress (100 dB, 1 kHz, 4 h/day, 6 days/week) for 1–4 weeks. The systolic blood pressure was significantly increased after rats were exposed to noise stress for 3 weeks. The relaxant responses of isolated mesenteric arterial rings to endothelium-dependent vasodilators (A23187 and acetylcholine) in noise-treated rats were significantly less than those in control rats. This difference in response to acetylcholine still existed in the presence of methylene blue or Nω-nitro-L-arginine. On the other hand, the responses to the endothelium-independent vasodilator nitroglycerin were not affected in rats exposed to noise stress. The attenuation to endothelium-dependent vasodilators during noise stress may result in increasing peripheral vascular resistance and thus elevate blood pressure. This indicates that noise-induced hypertension may be partly due to the alterations of endothelial activity.

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Authors and Affiliations

  1. Department of Pharmacology, National Defense Medical Center, PO Box 90048-504, 100, Taipei, Taiwan (ROC)

    C. C. Wu, S. J. Chen & M. H. Yen

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  1. C. C. Wu
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  2. S. J. Chen
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  3. M. H. Yen
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Wu, C.C., Chen, S.J. & Yen, M.H. Attenuation of endothelium-dependent relaxation in mesenteric artery during noise-induced hypertension. J Biomed Sci 1, 49–53 (1993). https://doi.org/10.1007/BF02258339

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  • DOI: https://doi.org/10.1007/BF02258339

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