Abstract
Our scientific language is often misleading. We speak, for example, of virilizing progestins when we should be speaking of “dihydrotestosterone-like” progestins because genital virilization is normally brought about by DHT. We speak of the anti-libidinal properties of antiandrogens as though we knew that their mechanism of action was through the blockage of androgen receptors; some of these agents are antiestrogenic and progestational as well. Until we know the mechanism of action of androgens, estrogens, antiandrogens, antiestrogens, aromatase inhibitors, and reductase inhibitors we should be cautious in our terminology. All hormones and their antagonists have multiple effects.
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Clemens, L. G., and Gladue, B. A. (1978). Feminine sexual behavior in rats enhanced by prenatal inhibition of androgen aromatization.Horm. Behav. 11: 190–201.
Ehrhardt, A. A., and Meyer-Bahlburg, H. F. L. (1981). Effects of prenatal sex hormones on gender-related behavior.Science 211: 1312–1318.
Erskine, M.S., Marcus, J. I., and Baum, M. J., (1980). Effect of anti-androgen and 5α-reductase inhibitor on hormone-induced sexual behavior during pregnancy in the rat.Biol. Reprod. 23: 767–775.
Etgen, A. M., and Whalen, R. E. (1979). Masculinization and defeminization induced in female hamsters by neonatal treatment with estradiol, RU-2858 and nafoxidine.Horm. Behav. 12: 211–217.
Imperato-McGinley, J., Guerrero, L., Gautier, T., and Peterson, R. E. (1974). Steroid 5α-reductase deficiency in man: An inherited form of male pseudohermaphroditism.Science 186: 1213–1215.
Landau, I. T. (1980). Facilitation of male sexual behavior in adult male rats by the aromatization inhibitor, 1,4,6-androstatriene-3,17-dione (ATD).Physiol. Behav. 25: 173–177.
Laschet, U., and Laschet, L. (1975). Antiandrogens in the treatment of sexual deviations of men.J. Steroid Biochem. 6: 821–826.
Lieberburg, I., Wallach, G., and McEwen, B. S. (1977). The effect of an inhibitor of aromatization (1,4,6,-androstatriene-3,17-dione) and an anti-estrogen (CI-628) on in vivo formed testosterone metabolites recovered from neonatal rat brain tissues and purified cell nuclei. Implications for sexual differentiation of the rat brain.Brain Res. 128: 176–181.
McEwen, B. S., Lieberburg, I., Chaptal, C., and Krey, L. C. (1977). Aromatization: Important for sexual differentiation of the brain.Horm. Behav. 9: 249–263.
Neri, R. O., Monahan, M. D., Meyer, J. G., Alfonso, B. A., and Tabachnik, I. A. (1967). Biological studies on an antiandrogen (SH714).Eur. J. Pharm. 1: 438–444.
Reinisch, J. M. (1981). Prenatal exposure to synthetic progestins increases potential for aggression in humans.Science 211: 1171–1173.
Södersten, P. (1974). Effects of an estrogen antagonist, MER-25, on mounting behavior and lordosis behavior in the female rat.Horm. Behav. 5: 111–127.
Stedman's Medical Dictionary (20th ed.). (1961). Williams & Wilkins, Baltimore.
Vreeburg, J. T. M., van der Vaart, P. D. M., and van der Schoot, P. (1977). Prevention of central defeminization, but not masculinization in male rats by inhibition.J. Endocrinol. 74: 375–382.
Whalen, R. E., and Etgen, A. M. (1978). Masculinization and defeminization induced in female hamsters by neonatal treatment with estradiol benzoate and RU-2858.Horm. Behav. 10: 170–177.
Whalen, R. E., and Hardy, D. F. (1970). Induction of receptivity in female rats and cats with estrogen and testosterone.Physiol. Behav. 5: 529–533.
Whalen, R. E., and Olsen, K. L. (1981). Role of aromatization in sexual differentiation: Effects of prenatal ATD treatment and neonatal castration.Horm. Behav. 15: 107–122.
Whalen, R. E., Peck, C. K., and LoPiccolo, J. (1966). Virilization of female rats by prenatally administered progestin.Endrocrinology 78: 965–970.
Wilson, J. D., George, F. W., and Griffin, J. E. (1981). The hormonal control of sexual development.Science 211: 1279–1284.
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Whalen, R.E. Multiple actions of steroids and their antagonists. Arch Sex Behav 13, 497–502 (1984). https://doi.org/10.1007/BF01541432
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DOI: https://doi.org/10.1007/BF01541432