Skip to main content
SpringerLink
Log in

Morphological manifestations of hereditary hypertrophic cardiomyopathy in W/SSM rats

  • Morphology and Pathomorphology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

A W/SSM strain of rats with hereditary hypertrophic cardiomyopathy has been created by inbreeding Wistar rats selected for an increased, sensitivity to the cataractogenic effect of high doses of galactose. It is shown that myocardial hypertrophy attended by a diffuse stroma collagenization, focal sclerotic changes, and signs of, chronic heart failure spontaneously develops in these animals.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. O. N. Grishaeva, N. A. Solov'eva, V. S. Gornostaev, and R. I. Salganik,Byull. Sib. Otdel. Akad. Med. Nauk SSSR, No 5-6, 102–105 (1988).

    Google Scholar 

  2. A. M. Zaidman, V. V. Kandaurov, N. A. Solov'eva, and I. R. Semenov,Spinal Column Pathology [in Russian], Leningrad (1984), pp. 54–57.

  3. F. Z. Meerson,Physiology of Adaptive Processes [in Russian], Moscow (1986), pp. 77–123.

  4. L. M. Nepomnyashchikh,Morphogenesis of the Principal General Pathological Processes of the Heart [in Russian], Novosibirsk (1991).

  5. The Prevention and Early Detection of Cardiomyopathy: Conclusions and Recommendations of the Conference of the World Health Organization,Byull. Vsem. Org. Zdravookhr.,64, No 3, 12–22 (1986).

    Google Scholar 

  6. D. E. Semenov and L. M. Nepomnyashchikh,Byull. Eksp. Biol. Med.,117, No 1, 93–95 (1994).

    Article  CAS  Google Scholar 

  7. L. A. Semenova, L. M. Nepomnyashchikh, and D. E. Semenov,Morphology of Plastic Insufficiency of Cardiomyocytes [in Russian], Novosibirsk (1985).

  8. N. A. Solov'eva, T. S. Morozkova, and R. I. Salganik,Genetika,11, No 5, 63–71 (1975).

    PubMed  Google Scholar 

  9. N. A. Solov'eva, E. Kh. Ginzburg, F. S. Kazarinova,et al., Vopr. Med. Khimii, No 6, 41–47 (1978).

    Google Scholar 

  10. N. A. Solov'eva, O. N. Grishaeva, Yu. A. Parik,et al., Vest. Ros. Akad. Med. Nauk., No 2, 31–34 (1994).

    Google Scholar 

  11. K. Hiroshi and S. Enomoto,Chem. Pharm. Bull. (Tokyo),29, No 4, 913–917 (1981).

    Google Scholar 

  12. J. Krieger and J. Huetterman,Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med.,48, No 6, 893–916 (1985).

    PubMed  CAS  Google Scholar 

  13. M. Kuwabara and P. Yveshion,,39, No 4, 451–456 (1981).

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Molecular Genetics, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk

    R. I. Salganik, N. A. Solov'eva, L. M. Nepomnyashchikh & D. E. Semenov

  2. Laboratory of General Pathological Anatomy, Research Institute of Regional Pathology and Pathomorphology, Seberian Division of the Russian Academy of Medical Sciences, Novosibirsk

    R. I. Salganik, N. A. Solov'eva, L. M. Nepomnyashchikh & D. E. Semenov

Authors
  1. R. I. Salganik
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. N. A. Solov'eva
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. L. M. Nepomnyashchikh
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. D. E. Semenov
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, No 8, pp. 203–207, August, 1994

Rights and permissions

Reprints and permissions

About this article

Cite this article

Salganik, R.I., Solov'eva, N.A., Nepomnyashchikh, L.M. et al. Morphological manifestations of hereditary hypertrophic cardiomyopathy in W/SSM rats. Bull Exp Biol Med 118, 900–904 (1994). https://doi.org/10.1007/BF02444460

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02444460

Key Words

Search

Navigation