Skip to main content
SpringerLink
Log in

Epithelium-dependent regulation of smooth muscle contractility of the airways

  • Biophysics and Biochemistry
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The contribution of calmodulin and protein kinase C to the regulation of epithelial relaxing factor production by the tracheal epithelium and the role of adenylate and guanylate cyclase in the realization of the effect of this factor on airway smooth muscles are studied by the mechanographic method with cascade perfusion. Calmodulin and protein kinase C are shown to participate in the production of relaxing factor by epitheliocytes, guanylate cyclase being the principal target in exposure of smooth muscles to epithelial relaxing factor.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. M. B. Baskakov, I. V. Kovalev, M. A. Medvedev, and N. P. Larionov,Byull. Eksp. Biol. Med.,97, No 4, 431–434 (1984).

    Article  CAS  Google Scholar 

  2. M. B. Baskakov, M. A. Medvedev, and B. I. Khodorov, in:Intracellular Signalization [in Russian], Moscow (1988), pp. 90–97.

  3. N. A. Medyedeva and O. S. Medvedev,Farmakol. Toksikol., No 5, 92–101 (1988).

    Google Scholar 

  4. I. M. Rakhmatullin, R. S. Fassakhov, R. M. Galyamov, and D. E. Tsiplakov,Byull. Eksp. Biol. Med.,113, No 5, 483–486 (1992).

    Google Scholar 

  5. V. P. Reutov and S. N. Orlov,Fiziologiya Cheloveka, No 1, 124–137 (1993).

    Google Scholar 

  6. L. M. Blayney, P. W. Gapper, and A. C. Newby,Biochem. J.,273, 803–806 (1991).

    PubMed  CAS  Google Scholar 

  7. S. E. Bryson and I. W. Rodger,Brit. J. Pharmacol.,92, 673–681 (1987).

    CAS  Google Scholar 

  8. L. Daffoncio, A. Hernandes, E. Martinotti, and C. Omini,Pharmacol. Res. Commun.,22, 49–58 (1990).

    Google Scholar 

  9. L. B. Fernandes, J. W. Paterson, and R. G. Godie,Brit. J. Pharmacol.,96, 117–124 (1989).

    CAS  Google Scholar 

  10. N. A. Flafahan, L. L. Aarhus, T. J. Rimele, and P. M. Vanhoutte,J. Appl. Physiol.,58, 834–838 (1985).

    Google Scholar 

  11. K. M. Macleod, K. H. Harris, and J. Diamond,Molec. Pharmacol.,32, 59–64 (1987).

    CAS  Google Scholar 

  12. S. Park and H. Rasmussen,Proc. Nat. Acad. Sci. USA,82, 8835–8839 (1985).

    Article  PubMed  CAS  Google Scholar 

  13. C. Wu and D. Bohr,Amer. J. Physiol.,261, H1411-H1416 (1991).

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Siberian Medical University, Tomsk

    L. V. Kapilevich, M. B. Baskakov, M. A. Medvedev, E. Yu. Petrov, M. V. Kuskov, V. Yu. Timofeev & I. V. Kovalev

Authors
  1. L. V. Kapilevich
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. B. Baskakov
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. A. Medvedev
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. E. Yu. Petrov
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. M. V. Kuskov
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. V. Yu. Timofeev
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. I. V. Kovalev
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, No 3, pp. 283–285, March, 1995

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kapilevich, L.V., Baskakov, M.B., Medvedev, M.A. et al. Epithelium-dependent regulation of smooth muscle contractility of the airways. Bull Exp Biol Med 119, 273–275 (1995). https://doi.org/10.1007/BF02445833

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02445833

Key Words

Search

Navigation