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Pharmacokinetics of prednisolone and its impact on cortisol kinetics in the blood serum of apparently healthy human subjects

  • Pharmacology and Toxicology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Individual characteristics of prednisolone and cortisol pharmacokinetics in five young healthy subjects administered prednisolone in a single oral dose of 25 mg are described. The results suggests that prednisolone inhibits the glucocorticoid function of the adrenal cortex. It is concluded that the pharmacokinetics of prednisolone can be assessed from the reductions in serum cortisol concentration which it causes.

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Authors and Affiliations

  1. Chair of Hospital Pediatrics, Course in Informatics, State Medical Academy, Nizhni Novgorod

    A. F. Chekalin & V. F. Rossokhin

Authors
  1. A. F. Chekalin
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  2. V. F. Rossokhin
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 122, No. 7, pp. 51–54, July, 1996

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Chekalin, A.F., Rossokhin, V.F. Pharmacokinetics of prednisolone and its impact on cortisol kinetics in the blood serum of apparently healthy human subjects. Bull Exp Biol Med 122, 695–697 (1996). https://doi.org/10.1007/BF02446026

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  • DOI: https://doi.org/10.1007/BF02446026

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