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Electrocardiographic examination of the heart in rats after injury to the myocardium

  • Pathological Physiology and General Pathology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

Three stages of myocardial healing were established in injury of the heart wall in rats (by means of electrodiathermocoagulator) and the following development of an infarct-like focus, i.e. acute, subacute and the stage of of scar formation. Changes in the electrocardiogram correspond to these stages.

In experiments with additional administration of biopreparations stimulating the regeneration after the heart in-injury the best effect was obtained by using the hydrolysate of the heat muscle. Thus, after the 10-fold administration of this hydrolysate a shortening of the subacute stage and the earlier appearance of the stage of scar formation was noted.

In this series of experiments a stable return of the electrocardiogram to the normal was noted 11 days after the the operation in 50% of the cases.

In comparing the physiological data with the histological one it was established that the normalization of the electrocardiogram corresponds to the time of regeneration of muscles at the site of the injury.

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Authors and Affiliations

  1. A. N. Severtsov Institute of Morphology of Animals, Academy of Sciences of the USSR, Moscow

    N. A. Zakharova

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  1. N. A. Zakharova
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Zakharova, N.A. Electrocardiographic examination of the heart in rats after injury to the myocardium. Bull Exp Biol Med 46, 1454–1457 (1958). https://doi.org/10.1007/BF00793483

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  • DOI: https://doi.org/10.1007/BF00793483

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