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Mechanism of the protective effect of succinic semialdehyde and its derivatives in hypoxia

  • Pharmacology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Preliminary injection of succinic semialdehyde into animals in experiments with hypoxia led to a lower concentration of free ammonia in their brain tissues than in control experiments in which the compound was not given. The enzyme system of the liver tissue catalyzes the oxidation of NAD · H2 by succinic semialdehyde and its derivatives with a free aldehyde group. The conversion of succinic semialdehyde and its derivatives in the liver tissue leading to the formation of the oxidized form of NAD, which is deficient in hypoxia, and the prevention of accumulation of free ammonia in the brain tissue by preliminary administration of succinic semialdehyde are the possible mechanisms of the antihypoxic properties of succinic semialdehyde and its derivatives.

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Authors
  1. A. M. Zubovskaya
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  2. R. U. Ostrovskaya
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  3. N. M. Tsybina
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Zubovskaya, A.M., Ostrovskaya, R.U. & Tsybina, N.M. Mechanism of the protective effect of succinic semialdehyde and its derivatives in hypoxia. Bull Exp Biol Med 78, 780–782 (1974). https://doi.org/10.1007/BF00799318

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  • DOI: https://doi.org/10.1007/BF00799318

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