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Effect of a highly purified factor from the thymus on cellular and humoral indices of immunity in thymectomized mice

  • Microbiology and Immunology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

In experiments on thymectomized adult CBA mice the effect of a homogeneous factor of polypeptide nature from the thymus, with mol. wt. about 5000 (thymarin-III) on the cellular and humoral indices of immunity was studied in animals. Thymectomy in animals was shown to sharply reduce the number of T-cells in the spleen. Correspondingly, the ability of the mice to produce both IgM- and IgG-antibody-forming cells and humoral antibodies against a thymus-dependent antigen (sheep's red blood cells) was sharply inhibited in the mice. Subcutaneous injection of thymarin-III in a dose of 1 μg/kg into the animals daily for 7 days completely restored the T-cell population of the spleen and restored the normal immunologic reactivity of the animals.

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Authors
  1. G. A. Belokrylov
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  2. V. G. Morozov
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  3. V. Kh. Khavinson
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  4. B. N. Sofronov
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Belokrylov, G.A., Morozov, V.G., Khavinson, V.K. et al. Effect of a highly purified factor from the thymus on cellular and humoral indices of immunity in thymectomized mice. Bull Exp Biol Med 86, 894–896 (1978). https://doi.org/10.1007/BF00801303

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  • DOI: https://doi.org/10.1007/BF00801303

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