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Immunologic reactivity of (C57BL/6 × A/Sn)F1 mice in mixed Mycoplasma-virus infection

  • Microbiology and Immunology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Mixed infection of hybrid mice, highly resistant to Rauscher virus, with this virus andMycoplasma arthritidis was accompanied by progressive inhibition of populations of splenic rosetteforming (REC) and plaque-forming (PFC) cells and led to induction of malignant erythroblastosis, cytologically identical with Rauscher's leukemia. During mixed infection of the hybrid mice withAcholeplasma laidlawii and Rauscher virus the immune response was almost completely suppressed on the 21st day and considerable splenomegaly was observed, but by the 62nd day of infection the RFC and PFC populations and also the weight of the spleens had regained the control level. The possible role of mycoplasmas in the induction and development of Rauscher's leukemia is discussed.

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Authors
  1. A. V. Sanin
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  2. A. V. Pronin
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  3. V. V. Khorobrykh
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  4. D. R. Kaulen
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Sanin, A.V., Pronin, A.V., Khorobrykh, V.V. et al. Immunologic reactivity of (C57BL/6 × A/Sn)F1 mice in mixed Mycoplasma-virus infection. Bull Exp Biol Med 88, 1041–1044 (1979). https://doi.org/10.1007/BF00799277

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  • DOI: https://doi.org/10.1007/BF00799277

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