Abstract
Leucine- and methionine-enkephalins have been synthesized by the successive growth of the peptide chain from the C-end by the method of polymeric activated esters based on 4-hydroxy-3-nitrobenzophenone with yields of 90 and 70%, respectively, calculated on the initial C-terminal amino acid. Polystyrene with 2% of divinylbenzene was used as the polymeric matrix. Using the synthesis of methionine-enkephalin as an example, the possibility has been shown of using polymeric activated esters for the synthesis of peptides with a free carboxy group.
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Leningrad State University. Translated from Khimiya Prirodnykh Soedinenii, No. 4, pp. 547–553, July–August, 1989.
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Grigor'ev, E.I., Chernova, S.V. Synthesis of enkephalins by the method of polymeric activated esters based on 4-hydroxy-3-nitrobenzophenone. Chem Nat Compd 25, 468–474 (1989). https://doi.org/10.1007/BF00597660
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DOI: https://doi.org/10.1007/BF00597660