Summary and conclusions
The potassium iodide saliva test, as described, is as useful as the test meal method1 for determining the rate of gastric emptying. When administered orally, atropine (1 mg.) is approximately equivalent to heteronium bromide (4.2 mg.), insofar as effect on gastric emptying is concerned.
The test meal method for determining gastric secretory activity demonstrated that, when administered orally, heteronium bromide had a significantly greater effect on gastric secretion than did atropine. This suggests that it may be possible to separate the effects of anticholinergic drugs on motility from the effects on secretion.
The doses of atropine and heteronium bromide used in this study did not produce any unusual or excessive untoward reactions. In these single dose studies they were equally acceptable to the patients.
This study was designed as a pharmacologic test using human subjects. It was not an experiment in therapeutics; therefore, the doses used were not in accord with those recommended for routine patient care. No implication is intended that these doses be used therapeutically.
Similar content being viewed by others
References
Hunt, J. N., andSpurrell, W. R. Pattern of emptying of human stomach.J Physiol 113:157, 1951.
Test, C. E., Nichols, R. L., Landau, R. L., Ricketts, H. T., andLonghead, R. A study of the “flat” oral glucose tolerance curve and its relation to rate of emptying of the stomach.Amer J Med Sci 231:69, 1965.
Baylin, G. J., Sanders, A., Isley, J. K., Shingflton, W. W., Haymans, J. C., Johnson, D. H., andRuffin, J. M. I131 blood levels correlated with gastric emptying determined radiographically. II. Fat test meal.Proc Soc Exp Biol Med 89: 54, 1955.
Sun, D. C. H., Shay, H., andWoloshin, H. J. Effect of tricyclamol on gastric emptying and intestinal transit. Comparative studies with placebos, single dose, and optimal effective dose.Amer J Dig Dis 4:282, 1959.
Hunt, J. N. Gastric emptying and secretion in man.Physiol Rev 39:491, 1959.
Penner, A., Hollander, F., andSaltzman, M. The gastric absorption of phenol red in humans.Amer J Dig Dis 5:657, 1938.
Cohn, B. N. E. Absorption of compound solution of iodine from the gastro-intestinal tract.With special reference to the absorption of free iodine. Arch Intern Med 49:950, 1932.
Karfl, L. Gastric absorption.Physiol Rev 25: 433, 1948.
Heath, C. W. andFullerton, H. W. The rate of absorption of iodide and glycine from the gastro-intestinal tract in normal persons and in disease conditions.J Clin Invest 14:475, 1935.
Smail, M. D., Bezman, A., Longarini, A. E., Fennell, A., andZamcheck, N. Absorption of potassium iodide from the gastio-intestinal tract.Proc Soc Exp Biol Med 106: 450, 1961.
Small, M., Longarini, A., andZamcheck, N. Disturbances of digestive physiology following acute drinking episodes in “skid-row” alcoholics.Amer J Med 27:575, 1959.
Chernish, S. M., andRosenak, B. D. The effect of a new anticholinergic drug, heteronium bromide, on basal gastric secietion.Amer J Dig Dis 70:697, 1965.
Author information
Authors and Affiliations
Additional information
The authors express their appreciation to Mr. Ralph Carmichael for the analysis of samples, the medical staff of the Marion County General Hospital, and to Mrs. Sharon Shariatzadeh and Mrs. Hilda Banks for their help and cooperation.
Rights and permissions
About this article
Cite this article
Chernish, S.M., Young, E.B., Rosenak, B.D. et al. A comparison of two methods of measurement of gastric emptying time. Digest Dis Sci 12, 761–774 (1967). https://doi.org/10.1007/BF02236241
Issue Date:
DOI: https://doi.org/10.1007/BF02236241