Abstract
Rectal biopsies from healthy control subjects, and from patients with Crohn's disease whose rectal mucosa appeared normal by sigmoidoscopy and light microscopy, were examined by scanning electron microscopy. Appearances within both groups were quite variable, and no clear differences between the groups could be distinguished.
Similar content being viewed by others
References
Present DH, Chapman ML, Cohen N, Janowitz HD: The correlation of sigmoidoscopy and rectal valve biopsy in granulomatous disease of the small bowel. Gastroenterology 52:1113, 1967
Korelitz BI, Sommers SC: Rectal biopsy in patients with Crohn's disease. Normal mucosa on sigmoidoscopy examination. J Am Med Assoc 237:2742–2744, 1977
Dyer NH, Stansfield AG, Dawson AM: The value of rectal biopsy in the diagnosis of Crohn's disease. Scand J Gastroenterol 5:491–496, 1970
Anderson FH, Bogoch A: Biopsies of large bowel in regional enteritis. Can Med Assoc J 98:150–153, 1968
Goodman MJ, Skinner JM, Truelove SC: Abnormalities in the apparently normal bowel mucosa in Crohn's disease. Lancet 1:275–278, 1976
Kavin H, Hamilton DG, Greasley RE, Eckert JD, Zuidema G: Scanning electron microscopy. A new method in the study of rectal mucosa. Gastroenterology 59:426–432, 1970
Siew S, Tedesco FJ: Scanning electron microscopy of human colonic biopsies as as aid in the diagnosis of clindamycin-associated colitis. Scanning Electron Microsc 2:187–194, 1977
Riddell RH, Levin B: Ultrastructure of the “transitional” mucosa adjacent to large bowel carcinoma. Cancer 40:2509–2522, 1977
Meisel JL, Bergman D, Graney D, Saunders DR, Rubin CE: Human rectal mucosa: proctoscopic and morphological changes caused by laxatives. Gastroenterology 72:1274–1279, 1977
Fenoglio CM, Richart RM, Kaye GI: Comparative electron microscopic features of normal, hyperplastic and adenomatous colonic epithelium. Gastroenterology 69:100–109, 1975
Karnovski M: A formaldehyde-glutaraldehyde fixative of high osmolality for use in electron microscopy. J. Clin Biol 27:137A, 1965
Riddell RH, Eisenstat L, Golomb H, Brynes R, Levin B: A low power SEM study of normal and colitic human large bowel. 33rd Annual Proceedings of Electron Microscopy Society of America, pp 418–419, 1975
Rickert RR, Carter HW: The gross, light microscopic and scanning electron microscopic appearance of the early lesions of Crohn's disease. Scanning Electron Microsc 11:179–186, 1977
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kaye, M.D., Brody, A.R., Whorwell, P.J. et al. Scanning electron microscopy of rectal mucosa in Crohn's disease. Digest Dis Sci 24, 369–375 (1979). https://doi.org/10.1007/BF01297123
Issue Date:
DOI: https://doi.org/10.1007/BF01297123