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Micronodular cirrhosis after thiabendazole

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Summary

Hepatotoxicity secondary to the administration of thiabendazole has been rare since this drug was produced in 1964. In 14 of 15 patients reported previously in the literature, severe intrahepatic cholestasis resolved within seven months of the onset of illness. A recent report documented the progression to cirrhosis in a 15th patient. We report the second case of a patient with intrahepatic cholestasis that developed after treatment with thiabendazole and progressed to severe micronodular cirrhosis.

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Authors and Affiliations

  1. Departments of Gastroenterology and Anatomic Pathology, Lahey Clinic Medical Center, Burlington, Massachusetts

    Michael A. Roy MD,  F. Warren Nugent MD & H. Thomas Aretz MD

Authors
  1. Michael A. Roy MD
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  2. F. Warren Nugent MD
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  3. H. Thomas Aretz MD
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Roy, M.A., Nugent, F.W. & Aretz, H.T. Micronodular cirrhosis after thiabendazole. Digest Dis Sci 34, 938–941 (1989). https://doi.org/10.1007/BF01540282

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  • DOI: https://doi.org/10.1007/BF01540282

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