Skip to main content
SpringerLink
Log in

Portal hypertension

Its effects on gastric function and ethanol-induced gastric mucosal damage in rats

  • Original Articles
  • Published:
Digestive Diseases and Sciences Aims and scope Submit manuscript

Abstract

The time-course effects of portal hypertension on gastric secretory function, mucosal blood flow, vascular permeability, and ethanol-induced gastric mucosal damage were examined in anesthetized rats. Partial ligation of the portal vein effectively produced portal hypertension one to three days later but the raised pressure returned to normal on the sixth day after ligation. This time-course effect coincided with reduced pepsin secretion and mucosal blood flow and also with potentiated ethanol-induced mucosal damage during the first to third days. These effects started to tail off on the sixth day. However, gastric acid output was significantly reduced on the third day, and this was strongest on the sixth day after operation. Portal vein ligation also reduced basal vascular permeability, which was markedly potentiated after ethanol treatment. It is concluded that: (1) portal vein blood pressure changes are a time-dependent process following ligation; (2) changes in gastric mucosal blood flow (GMBF) and lesion formation are closely related to portal hypertension; (3) gastric mucosal injury is associated with vascular damage, as evidenced by increased in vascular permeability; and (4) pepsin but not acid secretion is closely related to the state of the GMBF.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Baxter JN, Dobbs BR: Portal hypertensive gastropathy. J Gastroenterol Hepatol 3:635–644, 1988

    Google Scholar 

  2. McCormack TT, Sims J, Eyre-Brook I, Kennedy H, Goepel J, Johnson AG, Triger DR: Gastric lesions in portal hypertension: Inflammatory gastritis or congestive gastropathy? Gut 26:1226–1232, 1985

    Google Scholar 

  3. Papazian A, Braillon A, Dupas JL, Sevenet F, Capron JP: Portal hypertensive gastric mucosa: An endoscopic study. Gut 27:1204–1209, 1986

    Google Scholar 

  4. Dobbs BR, Hider RN, Baxter JN: Structural and functional changes of the gastric mucosa in rats with portal hypertension. J Gastroenterol Hepatol 6:350–354, 1991

    Google Scholar 

  5. Geraghty JG, Angerson W, Carter DC: The susceptibility of the gastric mucosa to injury in portal hypertension. Br J Surg 27:1204–1209, 1986

    Google Scholar 

  6. Sarfeh IJ, Tarnawski A, Maeda R, Raymont K, Mason GR, Ivey KJ: The gastric mucosa in portal hypertension: Effects of topical bile acid. Scand J Gastroenterol 19(suppl 92):189–194, 1984

    Google Scholar 

  7. Sarfeh IJ, Tarnawski A, Malki A, Mason GR, Mach T, Ivey KJ: Portal hypertension and gastric mucosal injury in rats. Gastroenterology 84:987–993, 1983

    Google Scholar 

  8. Mersereau WWA, Hinchey EJ: Effect of gastric acidity on gastric ulceration induced by hemmorrhage in the rat, utilizing a gastric chamber technique. Gastroenterology 64:1130–1135, 1973

    Google Scholar 

  9. Wong SH, Cho CH, Ogle CW: Protection by zinc sulphate against ethanol-induced ulceration: Preservation of the gastric mucosal barrier. Pharmacology 33:94–102, 1986

    Google Scholar 

  10. Berstad A: A modified hemoglobin substrate method for the estimation of pepsin in gastric juice. Scand J Gastroenterol 5:343–348, 1970

    Google Scholar 

  11. Shepherd AP, Riedel GL: Continuous measurement of intestinal mucosal blood flow by laser-Doppler velocimetry. Am J Physiol 242:G668-G672, 1982

    Google Scholar 

  12. Cho CH, Chen BW, Hui WM, Lam SK, Ogle CW: The role of the vagus nerve in the protective action of acid inhibition on ethanol-induced gastric mucosal damage in rats. J Gastroenterol Hepatol 7:178–183, 1992

    Google Scholar 

  13. Ankier SI, Whiteside ML: A simple procedure for the quantitative extraction of extravasated dye in skin tissue. Biochem Pharmacol 18:2197–2202, 1969

    Google Scholar 

  14. Harada M, Takeuchi M, Fukao T, Kataguri K: A simple method for the quantitative extraction of dye extravasated into the skin. J Pharm Pharmacol 23:218–219, 1971

    Google Scholar 

  15. Cho CH, Pfeiffer CJ, Misra HP: Ulcerogenic mechanism of ethanol and the action of sulphanilyl fluoride on the rat stomachin-vivo. J Pharm Pharmacol 43:495–498, 1990

    Google Scholar 

  16. Itoh M, Guth PH: The role of oxygen-derived free radicals in hemorrhagic shock-induced gastric lesions in the rat. Gastroenterology 88:1162–1167, 1985

    Google Scholar 

  17. Parks DA, Bulkley GB, Granger DN: The role of oxygen-derived free radicals in digestive tract diseases. Surgery 94:415–422, 1983

    Google Scholar 

  18. Cho CH: The inhibitory action of ethanol on the gastric mucosa and its interaction with the vagus in rats. Agents Actions 35:135–139, 1992

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pharmacology, Faculty of Medicine, The University of Hong Kong, 5 Sassoon Road, Hong Kong

    J. J. Ma MD, C. H. Cho PhD & C. W. Ogle MD

Authors
  1. J. J. Ma MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C. H. Cho PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. C. W. Ogle MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ma, J.J., Cho, C.H. & Ogle, C.W. Portal hypertension. Digest Dis Sci 38, 2203–2208 (1993). https://doi.org/10.1007/BF01299896

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01299896

Key Words

Search

Navigation