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Repair of Rat Gastric Mucosa (Effect of 16,16-Dimethyl Prostaglandin E2)

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Abstract

Prostaglandins protect the gastric mucosaagainst a variety of injurious agents and may acceleratethe recovery of the gastric mucosa following damage. Inprevious studies prostaglandins were given prior to the injurious agent, so it was not possibleto distinguish their potential effects on acceleratingrepair or reducing initial damage. We have investigatedthe effect of 16,16-dimethyl prostaglandin E2 (dmPGE2) on the repair of thegastric muscosa after injury induced by severalinjurious agents. dmPGE2 was given orally 15min prior to aspirin or sodium salicylate, or 30 minafter aspirin, sodium salicylate, or ethanol. dmPGE2 delivered priorto injury reduced the aspirin-induced fall in mucosalpotential difference (PD), but had no effect on thatinduced by sodium salicylate. dmPGE2administered after ASA injury significantly increased recovery of PD (P <0.05), but did not alter the rate of recovery of PD withother damaging agents. Histological damage was decreasedin rats treated with dmPGE2 after aspirincompared to aspirin-only-treated rats (P < 0.02).Exogenous dmPGE2 protects and restoresgastric mucosal integrity after aspirin damage but hasno effect on the repair of sodium salicylate and ethanolinjured mucosa, suggesting that repair of the gastric mucosaafter aspirin damage is enhanced by dmPGE2due to its ability to prevent ongoing damage, ratherthan directly enhancing repair processes.

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Authors
  1. G. A. Cook
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  2. S. L. Elliott
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  3. M. V. Skeljo
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  4. A. S. Giraud
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  5. N. D. Yeomans
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Cook, G.A., Elliott, S.L., Skeljo, M.V. et al. Repair of Rat Gastric Mucosa (Effect of 16,16-Dimethyl Prostaglandin E2). Dig Dis Sci 42, 654–660 (1997). https://doi.org/10.1023/A:1018828016573

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  • DOI: https://doi.org/10.1023/A:1018828016573

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