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Impaired Gastric Myoelectrical Activity in Patients with Chronic Renal Failure

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Abstract

Dysmotility and delayed emptying of the stomachhave been reported in patients with chronic renalfailure (CRF). The aim of this study was to investigatewhether gastric myoelectrical activity was impaired in patients with CRF using electrogastrography.The electrogastrogram (EGG) was recorded in 24symptomatic patients with CRF (15 with diabetes) and 12normal subjects. Two 30-min EGG recordings before and after a test meal were analyzed using spectralanalysis methods. It was found that patients with CRFshowed a significantly lower percentage of normal 2-4cpm slow waves in both fasting and fed states in comparison with healthy controls (in fastingstate: 88.9 ± 2.5% vs 67.4 ± 6.6%/63.27.0%, P < 0.01; in fed state: 89.6 ± 1.8% vs64.6 ± 6.2%/62.0 ± 8.3%, P < 0.01;controls vs diabetic patients/nondiabetic patients). Both patient groups showed a significantlyhigher prevalence of the abnormal EGG, which was definedas the percentage of 2-4 cpm slow waves lower than 70%(fasting state: 8% vs 60%/56%, P < 0.01/0.05; fed state: 0% vs 53%/56%, P < 0.005/0.002;controls vs diabetic patients/nondiabetic patients). Nosignificant difference was observed in the regularity ofthe gastric slow waves between the two patient groups. The healthy controls showed a significantincrease in the dominant power and frequency of the EGGafter the test meal. However, this increase was absentin the two patient groups. It was concluded that patients with chronic renal failure haveabnormal gastric myoelectrical activity, includingimpaired regularity of the gastric slow wave and afailed increase in the power of the EGG at 3 cpm.Electrogastrography is an attractive noninvasive method for thestudy of gastric motility in patients with severechronic renal failure.

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REFERENCES

  1. Black DAK: Diagnosis and renal disease. In Renal Disease, 4th ed. DAK Black (ed). St. Louis, Missouri, Blackwell, 1980

    Google Scholar 

  2. Ravelli AM, Ledermann SE, Trompeter RS, Bisset WM, Milla PJ: Mechanisms of anorexia and vomiting in children with chronic renal failure. Gut 33:W70, 1992

    Google Scholar 

  3. Dumitrascu DL, Barnert J, Kirschner T, Weinbeck M: Antral emptying of semisolid meal measured by real-time ultrasonography in chronic renal failure. Dig Dis Sci 40(3):636-644, 1995

    Google Scholar 

  4. You CH, Chey WY, Lee KY: Gastric and small intestinal myoelectrical dysrhythmia associated with chronic intractable nausea and vomiting. Ann Intern Med 95:449-451, 1981

    Google Scholar 

  5. Stoddard CJ, Smallwood RH, Duthie HL: Electrical arrhythmias in the human stomach. Gut 22:705-712, 1981

    Google Scholar 

  6. Coe FL, Brenner BM: Approach to patients with diseases of the kidneys and urinary tract. In Harrison's Principles of Internal Medicine, 11th ed. New York, McGraw-Hill, 1987

    Google Scholar 

  7. Ravelli AM, Ledermann SE, Trompeter RS, Milla PJ: Gastric antral myoelectrical activity in children with chronic renal failure. In Electrogastrography: Principles and Applications. J Chen, RW McCallum (eds). New York, Raven, 1994, pp 411-418

    Google Scholar 

  8. Alvarez WC: The electrogastrogram and what it shows. JAMA 78:1116-1118, 1992

    Google Scholar 

  9. Smout AJPM, van der Schee EJ, Grashuis JL: What is measured in electrogastrography? Dig Dis Sci 25:179-187, 1980

    Google Scholar 

  10. Abell TL, Malagelada J-R: Glucagon-evoked gastric dysrhythmia in humans shown by an improved electrogastrographic technique. Gastroenterol 88:1932-1940, 1985

    Google Scholar 

  11. Hamilton JW, Bellahsene B, Reichelderfer M, Webster JG, Bass P: Human electrogastrograms: Comparison of surface and mucosal recordings. Dig Dis Sci 31:33-39, 1986

    Google Scholar 

  12. Familoni BO, Bowes KL, Kingma YJ, Cote KR: Can transcutaneous recordings detect gastric electrical abnormalities? Gut 32:141-146, 1991

    Google Scholar 

  13. Chen J, Schirmer BD, McCallum RW: Serosal and cutaneous recordings of gastric myoelectrical activity in patients with gastroparesis. Am J Physiol 266:G90-G98, 1994

    Google Scholar 

  14. Geldof H, van der Schee EJ, Grashuis JL: Electrogastrographic characteristics of interdigestive migrating complex in humans. Am J Physiol 250:G165-G171, 1986

    Google Scholar 

  15. Chen J, Richards RD, McCallum RW: Identification of gastric contractions from the cutaneous electrogastrogram. Am J Gastroenterol 89:79-85, 1994

    Google Scholar 

  16. Kim CH, Zinsmeister AR, Malagelada JR: Effect of gastric dysrhythmia on postcible motor activity of the stomach. Dig Dis Sci 33:193-199, 1988

    Google Scholar 

  17. You CH, Lee KY, Chey WY, Menguy R: Electrogastrographic study of patients with unexplained nausea, bloating and vomiting. Gastroenterology 79:311-314, 1980

    Google Scholar 

  18. Stern RM, Kenneth LK, Leibowitz HW, Lindblad IM, Shupert CL, Stewart WR: Tachygastria and motion sickness. Aviat Space Environ Med 56:1074-1077, 1985

    Google Scholar 

  19. Sun WM, Smout A, Malbert C, Edelbroek MAL, Jones K, Dent J, Horowitz M: Relationship between surface electrogastrography and antropyloric pressure. Am J Physiol 31:G424-G430, 1994

    Google Scholar 

  20. Walsh JW, Halser WL, Nugent CE, Owyang C: Progesterone and estrogen are potential mediators of gastric slow-wave dysrhythmia in nausea of pregnancy. Am J Physiol 270(33):G506-G514, 1996

    Google Scholar 

  21. Abell TL, Malagelada J-R, Lucas AR, et al: Gastro-mechanical and neurohormonal function in anorexia nervosa. Gastroenterology 93:958-965, 1987

    Google Scholar 

  22. Cucchiara S, Riezzo G, Minella R, Vallone G, Vallone PF, Giorgio I, Auricchio S: Electrogastrography in nonulcer dyspepsia. Arch Dis Child 67:613-617, 1992

    Google Scholar 

  23. Koch KL: Gastric dysrhythmia and the current status of electrogastrography. Pract Gastroenterol 13(4):37-44, 1989

    Google Scholar 

  24. Desvarannes SB, Mizafi M, Dubois A: Relation between post-prandial gastric emptying and cutaneous electrogastrogram in primates. Am J Physiol 261:G248-G255, 1991

    Google Scholar 

  25. Chen JDZ, Pan J, McCallum RW: Clinical significance of gastric myoelectrical dysrhythmia. Dig Dis Sci 13:275-290, 1995

    Google Scholar 

  26. Hasler WL, Soudah HC, Dulai G, Owyang C: Mediation of hyperglycemia-evoked gastric slow-wave dysrhythmias by endogenous prostaglandins. Gastroenterology 108(3):727-736, 1995

    Google Scholar 

  27. Jebbink HJ, Bruijs PP, Bravenboer B, Akkermans LM, van Berghe-Hennegouwen GP, Smout AJ: Gastric myoelectrical activity in patients with type I diabetes mellitus and autonomic neuropathy. Dig Dis Sci 39(11):2376-2383, 1994

    Google Scholar 

  28. Chen J: A computerized data analysis system for electrogastrogram. Comp Biol Med 22:45-58, 1992

    Google Scholar 

  29. Chen J, Stewart WR, McCallum RW: Spectral analysis of episodic rhythmic variations in the cutaneous electrogastrogram. IEEE Trans Biomed Eng 40:128-135, 1993

    Google Scholar 

  30. Chen J, McCallum RW: Gastric slow wave abnormalities in patients with gastroparesis. Am J Gastroenterol 87:477-482, 1992

    Google Scholar 

  31. Wright RA, Clemente R, Wathen R: Gastric emptying in patients with chronic renal failure receiving hemodialysis. Arch Intern Med 144:495-496, 1984

    Google Scholar 

  32. McNamee PT, Moore GW, McGeown MG, Doherty CC, Collins BJ: Gastric emptying in chronic renal failure. Br Med J 291:310-311, 1985

    Google Scholar 

  33. Freeman JG, Cobden I, Heaton A, Keir M: Gastric emptying in chronic renal failure. Br Med J 291:1048, 1985 (letter)

    Google Scholar 

  34. Soffer EE, Geva B, Helman C, Avni Y, Bar-Meir S: Gastric emptying in chronic renal failure patients on hemodialysis. J Clin Gastroenterol 9:651-653, 1987

    Google Scholar 

  35. Brown-Cartwright D, Smith HJ, Feldman M: Gastric emptying of an indegestible solid in patients with end-stage renal disease on continuous ambulatory peritoneal dialysis. Gastroenterology 95:49-51, 1988

    Google Scholar 

  36. Chen JDZ, Lin ZY, Pan J, McCallum RW: Abnormal gastric myoelectrical activity and delayed gastric emptying in patients with symptoms suggestive of gastroparesis. Dig Dis Sci (in press)

  37. Koch KL, Stewart WR, Stern R: Effect of barium meals on gastric electromechanical activity in man. Dig Dis Sci 32:1217-1222, 1987

    Google Scholar 

  38. Geldof H, van der Schee EJ, Smout AJPM: Myoelectrical activity of the stomach in gastric ulcer patients: An electrogastrographic study. J Gastrointest Motil 1:122-130, 1989

    Google Scholar 

  39. Chen J, McCallum RW: The response of electrical activity in normal human stomach to water and solid meals. Med Biol Eng Comput 29:351-357, 1991

    Google Scholar 

  40. Chen J, McCallum RW (eds): Electrogastrography: Principles and Applications. New York, Raven, 1994

    Google Scholar 

  41. Chen J, Davenport K, McCallum RW: Effect of fat preload on gastric myoelectrical activity in normal humans. J Gastroinest Motil 5:281-287, 1993

    Google Scholar 

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Authors
  1. Xuemei Lin
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  2. Mark H. Mellow
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  3. Leroy Southmayd
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  4. Jie Pan
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  5. J.D.Z. Chen
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Lin, X., Mellow, M.H., Southmayd, L. et al. Impaired Gastric Myoelectrical Activity in Patients with Chronic Renal Failure. Dig Dis Sci 42, 898–906 (1997). https://doi.org/10.1023/A:1018856112765

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