Abstract
This study demonstrates that luteinizing hormone (LH) release may occur despite sustained elevations of estradiol E2 in women receiving human menopausal gonadotropin. Mean levels of E2 did not correlate with the LH surge, however, the follicle number and a rapid rise in E2 did. Therefore, it appears that the protective influence of inhibitory proteins secreted by multiple follicles can be overridden, allowing spontaneous LH release.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Kerin J: Ovulation detection in the human. Clin Reprod Fertil 1982;1:27–54
Lindner HR, Amsterdam A, Salomon Y, Tsafrir A, Nimrod A, Lamprecht S, Zor UY, Koch Y: Intraovarian factors in ovulations: Determinants of follicular response to gonadotrophins. J Reprod Fer 1977;51:215–235
Yen SSC, Leim A: The apparent paradox of the negative and positive feedback control system of gonadotropin secretion. Am J Obstet Gynecol 1976;126:942–950
Kerin JFP, Wames GM, Crocher J, et al.: Three hour urinary radioimmunoassay for luteinizing hormone to detect onset of preovulatory LH surge. Lancet 1980;2:430–431
Wu CH, Lowchock: Daily blood hormone levels related to the luteinizing hormone surge in anovulatory cycles. Fertil Steril 1983;39:39–43
Jones HW, Acosta AA, Mascon C, Andrews MD, Garcia JE,et al.: Three years of in vitro fertilization at Norfolk. Fertil Steril 1984;42:826–834
diZerga GS, Hodgen GD: The primate ovarian cycle: supression of human menopausal gonadotropin-induced follicular growth in the presence of the dominant follicle. J Clin Endocrin Metab 1980;50:819–825
Schenken RS, Hodgen GD: Follicle-stimualting hormone induced ovarian hyperstimulation in monkeys: Blockade of the luteinizing hormone surge. J Clin Endocrinol 1983;57:50–55
Vargyas JM, Shangold GM, Battin DA: Comparison of clomiphene citrate and human menopausal gonadotropins regimen for ovarian hyperstimulation in human IVF-ER. Presented at the 40th annual meeting of the American Fertility Society, New Orleans, April 1984
Marrs RP, Saito H, Yee B, Sato F, Brown J: Effect of variation of in vitro culture techniques upon oocyte fertilizationembryo development in human in vitro fertilization procedures. Fertil Steril 1984;41:519–523
Marrs RP: Unpublished data, 1986
Marrs RP, Vargyas JM, Gibbons WE, Saito H, Mishell DR Jr: A modified technique of human in vitro fertilization and embryo transfer. Am J Obstet Gynecol 1983;147:318–322
Ferraretti AP, Garcia JE, Acosta AA, Seegar Jones GE: Serum LH during ovulation induction for in vitro fertilization in normal menstruating women. Fertil Steril 1983; 40:742–747.
Marrs RP, Lobo R, Campeau JD, Nakamura RM, Brown J, Ujita EL, diZerega GS: Correlation of human follicular fluid inhibin activity with spontaneous and induced follicle maturation. J Clin Endocrinol Metab 1984;58:704–709
Hodgen GD: The dominant ovarian follicle. Fertil Steril 1982;38:281–300
Littman BA, Hodgen GD: A comprehensive dose-response study of clomiphene citrate for enhancement of the primate ovarian/menstrual cycle. Fertil Steril 1984;31S
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Vargyas, J.M., Marrs, R.P. Endogenous luteinizing hormone release using human menopausal gonadotropins for in vitro fertilization. J Assist Reprod Genet 4, 107–110 (1987). https://doi.org/10.1007/BF01555449
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01555449