Abstract
Nucleoside (NDP) diphosphate kinases are oligomeric enzymes. Most are hexameric, but somebacterial enzymes are tetrameric. Hexamers and tetramers are constructed by assemblingidentical dimers. The hexameric structure is important for protein stability, as demonstratedby studies with natural mutants (the Killer-of-prune mutant ofDrosophila NDP kinase andthe S120G mutant of the human NDP kinase A in neuroblastomas) and with mutants obtainedby site-directed mutagenesis. It is also essential for enzymic activity. The function of the tetrameric structure is unclear.
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REFERENCES
Abdulaev, N. G., Karaschuk, G. N., Ladner, J. E., Kakuev, D. L., CYakhyaev, A. V., Tordova, M., Gaidarov, I. O., Popov, V. I., Fujiwara, J. H., Chinchilla, D., Eisenstein, E., Gilliland, G. L., and Ridge, K. D. (1998). Biochemistry 37, 13958-67.
Agarwal, R. P., and Parks, R. E., Jr. (1971). J. Biol. Chem. 246, 2258-2264.
Agarwal, R. P., Robison, B., and Parks, R. E., Jr. (1978).Methods Enzymol. 51, 376-386.
Agou, F., Raveh, S., Mesnildrey, S., and Vé ron, M. (1999). J. Biol. Chem. 274, 19630-19638.
Almaula, N., Lu, Q., Delgado, J., Belkin, S., and Inouye, M. (1995). J. Bacteriol. 177, 2524-9.
Ann, K. S., and Nelson, D. L. (1996). J. Eukary. Microbiol. 43, 365-372.
Biggs, J., Tripoulas, N., Hersperger, E., Dearolf, C., and Shearn, A. (1988). Genes Develop. 2, 1333-1343.
Biondi, R. M., Véron, M., Walz, K., and Passeron, S. (1995). Arch. Biochem. Biophys. 323, 187-194.
Brodbeck, M., Rohling, A., Wohlleben, W., Thompson, C. J., and Susstrunk, U. (1996). Eur. J. Biochem. 239, 208-213.
Buczynski, G., and Potter, R. L. (1990). Biochim. Biophys. Acta 1041, 296-304.
Chang, C. L., Zhu, X. X., Thoraval, D. H., Ungar, D., Rawwas, J., Hora, N., Strahler, J. R., Hanash, S. M., and Radany, E. (1994). Nature 370, 335-336.
Chang, C. L., Strahler, J. R., Thoraval, D. H., Qian, M. G., Hinderer, R., and Hanash, S. M. (1996). Oncogene 12, 659-667.
Cheng, Y. C., Agarwal, R. P., and Parks, R. E., Jr. (1971). Biochemistry 10, 2139-2143.
Cheng, Y. C., Robison, B., and Parks, R. E., Jr. (1973). Biochemistry 12, 5-10.
Chiadmi, M., Moréra, S., Lascu, I., Dumas, C., Le Bras, G., Véron, M., and Janin, J. (1993). Structure 1, 283-293.
Chothia, C., and Lesk, A. M. (1986). EMBO J. 5, 823-826.
D'Alessio, G. (1999). Progr. Biophys. Mol. Biol. 72, 271-198.
Dumas, C., Lascu, I., Moréra, S., Glaser, P., Fourme, R., Wallet, V., Lacombe, M.-L., Véron, M., and Janin, J. (1992). EMBO J. 11, 3203-8.
Erent, M., Gonin, P., Cherfils, J., Tissier, P., Agou, F., Giartosio, A., Sarger, C., Lacombe, M.-L., Konrad, M., and Lascu, I., in preparation.
Erent, M. (1997). Ph.D. thesis, University of Bordeaux, Bordeaux France.
Franke, I., Meiss, G., and Pingoud, A. (1999) J. Biol. Chem. 274, 825-832.
Giartosio, A., Erent, M., Cervoni, L., Moréra, S., Janin, J., Konrad, M., and Lascu, I. (1996). J. Biol. Chem. 271, 17845-17851.
Gilles, A.-M., Presecan, E., Vonica, A., and Lascu, I. (1991). J. Biol. Chem. 266, 8784-8789.
Goodsell, D. S., and Olson, A. J. (1993). Trends Biochem. Sci. 18, 65-68.
Guignard, F., and Markert, M. (1996). Biochem. J. 316, 233-238.
Hemmerich, S., and Pecht, I. (1992). Biochemistry 31, 4580-4587.
Huitorel, P., Simon, C., and Pantaloni, D. (1984). Eur. J. Biochem. 144, 233-241.
Ingraham J. L., and Ginther, C. L. (1978). Methods Enzymol. 51, 371-375.
Janin, J. (1995). Biochimie 77, 497-505.
Janin, J., Miller, S., and Chothia, C. (1988). J. Mol. Biol. 204, 155-164.
Janin, J., Dumas, C., Moréra, S., Xu, Y., Meyer, P., Chiadmi, M., and Cherfils, J. (2000). J. Bioenerg. Biomembr. 32, 213-224.
Jong, A. Y., and Ma, J. J. (1991). Arch. Biochem. Biophys. 291, 241-246.
Karlsson, A., Mesnildrey, S., Xu, Y., Morera, S., Janin, J., and Veron, M. (1996). J. Biol. Chem. 271, 19928-19934.
Kimura, N., and Shimada, N. (1988). J. Biol. Chem. 263, 4647-4653.
Kohlhoff, M., Dahm, A., and Hensel, R. (1996). FEBS Lett. 383, 245-250.
Kolatkar, P. R., Hackert, M. L., and Riggs, A. F. (1994).J. Mol. Biol. 237, 87-97.
Kowluru, A., and Metz, S. A. (1994). Biochem. 33, 12495-503.
Koyama, K., Yokoyama, M., Koike, T., Ohtsuki, K., and Ishida, N. (1984). J. Biochem. (Tokyo) 95, 925-935.
Lacombe, M.-L., Milon, L., Munier, A., Mehus, J. G., and Lambeth, D. O. (2000). J. Bioenerg. Biomembr. 32, 245-256.
Lam, S. C., and Packham, M. A. (1986).Biochem. Pharmacol. 35, 4449-4455.
Lambeth, D. O., Mehus, J. G., Ivey, M. A., and Milavetz, B. I. (1997). J. Biol. Chem. 272, 24604-24611.
Lascu, I., Charlotte, A., Limbourg-Bouchon, B., and Veron, M. (1992). J. Biol. Chem. 267, 12775-12781.
Lascu, I., Deville-Bonne, D., Glaser, P., and Veron, M. (1993). J. Biol. Chem. 268, 20268-20275.
Lascu, I., Schaertl, S., Wang, C., Sarger, C., Giartosio, A., Briand, G., Lacombe, M.-L., and Konrad, M. (1997). J. Biol. Chem. 272, 15599-15602.
Mehus, J. G., Deloukas, P., and Lambeth, D. O. (1999). Human Genet. 104, 454-459.
Mesnildrey, S., Agou, F., Karlsson, A., Deville-Bonne, D., and Véron, M. (1998). J. Biol. Chem. 273, 4436-4442.
Milon, L., Meyer, P., Chiadmi, M., Munier, A., Johansson, M., Karlsson, A., Lascu, I., Capeau, J., Janin, J., and Lacombe, M.-L. (2000). J. Biol. Chem. 275, 14264-14272.
Moréra, S., Lacombe, M.-L., Xu, Y., LeBras, G., and Janin, J. (1995). Structure 3, 1307-1314.
Moréra, S., LeBras, G., Lascu, I., Lacombe, M.-L., Vé ron, M., and Janin, J. (1994). J. Mol. Biol. 243, 873-890.
Munier, A., Feral, C., Milon, L., Pinon, V. P., Gyapay, G., Capeau, J., Guellaen, G., and Lacombe, M.-L. (1998). FEBS Lett. 434, 289-294.
Munoz-Dorado, J., Inouye, S., and Inouye, M. (1990). J. Biol. Chem. 265, 2707-2712.
Nickerson, J. A., and Wells, W. W. (1984). J. Biol. Chem. 259, 11297-11304.
Nomura, T., Fukui, T., and Ichikawa, A. (1991). Biochim Biophys Acta 1077, 47-55.
Ogura, Y., Yoshida, Y., Ichimura, K., Aoyagi, C., Yabe, N., and Hasunuma, K. (1999). Eur. J. Biochem. 266, 709-714.
Ohtsuki, K., Yokoyama, M., Koike, T., and Ishida, N. (1984). Biochem. Intern. 8, 715-723.
Ouatas, T., Abdallah, B., Gasmi, L., Bourdais, J., Postel, E., and Mazabraud, A. (1997). Gene 194, 215-225.
Padmanadhan, B., Katayanagi, K., Kimura, N., and Matsuzaki, T. (1999). Proc. 3rd Intern. Congr. Genet. Biochem. Physiol. nm23/NDP Kinases, Bordeaux, Abstr. P13.
Palmieri, R., Yue, R. H., Jacobs, H. K., Maland, L., Wu, L., and Kuby, S. A. (1973). J. Biol. Chem. 248, 4486-4499.
Parge, H. E., Arvai, A. S., Murtari, D. J., Reed, S. I., and Tainer, J. A. (1993) Science 262, 387-395.
Pedersen, P. L. (1968). J. Biol. Chem. 243, 4305-4311.
Polosina, Y., Jarrell, K. F., Fedorov, O. V., and Kostyukova, A. S. (1998). Extremophiles 2, 333-338.
Porumb, H., Vancea, D., Muresan, L., Presecan, E., Lascu, I., Petrescu, I., Porumb, T., Pop, R., and Barzu, O. (1987). J. Biol. Chem. 262, 4610-4615.
Postel, E. H., Weiss, V. H., Beneken, J., and Kirtane, A. (1996). Proc. Natl. Acad. Sci. USA 93, 6892-6897.
Presecan, E., Vonica, A., and Lascu, I. (1989). FEBS Lett. 250, 629-632.
Price, N. C. (1994). In Mechanisms of protein folding (R. H. Pain (Ed.) IRL Press, Oxford, pp. 160-193.
Schaertl, S. (1996). FEBS Lett 394, 316-320.
Sedmak, J., and Ramaley, R. (1971). J. Biol. Chem. 246, 5365-72.
Sellam, O., Veron, M., and Hildebrandt, M. (1995). Mol. Microbiol. 16, 79-85.
Sommer, D., and Song, P. S. (1994). Biochim Biophys. Acta 1222, 464-470.
Swain, M. S., and Lebherz, H. G. (1986). Arch. Biochem. Biophys. 244, 35-41.
Tepper, A. D., Dammann, H., Bominaar, A. A., and Veron, M. (1994). J. Biol. Chem. 269, 32175-32180.
Timmons, L., and Shearn, A. (1997). Advan. Genet. 35, 207-252.
Tsai, C. J., Xu, D., and Nussinov, R. (1997). Protein Sci. 6, 1793-1805.
Tsuiki, H., Nitta, M., Furuya, A., Hanai, N., Fujiwara, T., Inagaki, M., Kochi, M., Ushio, Y., Saya, H., and Nakamura, H. (2000). J. Cell Biochem. 76, 254-269.
Ulloa, R. M., Muschietti, J. P., Veron, M., Torres, H. N., and Tellez-Inon, M. T. (1995). Mol. Biochem. Parasitol. 70, 119-129.
Webb, P. A., Perisic, O., Mendola, C. E., Backer, J. M., and Williams, R. L. (1995). J. Mol. Biol. 251, 574-587.
Williams, R. L., Oren, D. A., Munoz-Dorado, J., Inouye, S., Inouye, M., and Arnold, E. (1993). J. Mol. Biol. 234, 1230-1247.
Wilson, T. J., Maroudas, P., Howlett, G. J., and Davidson, B. E. (1994). J. Mol. Biol. 238, 309-318.
Yang, L. M., and Lamppa, G. K. (1996). Biochim. Biophys. Acta 1294, 99-102.
Zhang, D., and Chang, K. J. (1992). Chin. Med. Sci. J. 7, 152-156.
Zhang, J., Fukui, T., and Ichikawa, A. (1995). Biochim. Biophys. Acta 1248, 19-26.
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Lascu, I., Giartosio, A., Ransac, S. et al. Quaternary Structure of Nucleoside Diphosphate Kinases. J Bioenerg Biomembr 32, 227–236 (2000). https://doi.org/10.1023/A:1005580828141
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DOI: https://doi.org/10.1023/A:1005580828141