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Multicompartment models of cancer chemotherapy incorporating resistant cell populations

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Abstract

The pharmacokinetics of antineoplastic drugs based on compartmental models are combined with deterministic exponential growth models of tumors containing drug-resistant and sensitive cells. Model predictions for single-drug therapy are compared with in vivodata obtained by other investigators for L1210 t-cell leukemia in mice treated with BCNU and AraC and for in vitrotreatment of L1210 with Ara-C. The model and data compare favorably in terms of rate of tumor growth and duration of drug action for both constant infusion and bolus delivery of the drugs.

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Authors and Affiliations

  1. Department of Electrical Engineering, University of Sydney, 2006, Sydney, NSW, Australia

    Hiep Nguyen Duc & Peter M. Nickolls

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  1. Hiep Nguyen Duc
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  2. Peter M. Nickolls
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The work described in this paper was supported by the National Health and Medical Research Council of Australia.

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Duc, H.N., Nickolls, P.M. Multicompartment models of cancer chemotherapy incorporating resistant cell populations. Journal of Pharmacokinetics and Biopharmaceutics 15, 145–177 (1987). https://doi.org/10.1007/BF01062341

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  • DOI: https://doi.org/10.1007/BF01062341

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