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Potential pitfalls in the conventional pharmacokinetic studies: Effects of the initial mixing of drug in blood and the pulmonary first-pass elimination

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Abstract

The classical concept of assuming that an i.v. dose instantaneously distributes into the central or plasma compartment is reviewed, as is the potential for pulmonary first-pass effect. Based on available literature, the concept is shown to lead to serious errors in estimating pharmacokinetic parameters, particularly for drugs with high clearance.

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Authors and Affiliations

  1. Clinical Pharmacokinetics Laboratory and Department of Pharmacy, College of Pharmacy, University of Illinois at the Medical Center, 60612, Chicago, Illinois

    Win L. Chiou

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Chiou, W.L. Potential pitfalls in the conventional pharmacokinetic studies: Effects of the initial mixing of drug in blood and the pulmonary first-pass elimination. Journal of Pharmacokinetics and Biopharmaceutics 7, 527–536 (1979). https://doi.org/10.1007/BF01062393

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  • DOI: https://doi.org/10.1007/BF01062393

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