Abstract
Accumulation factors for the peripheral compartment in a two-compartment open model are derived. These expressions are contrasted with some previously published statements concerning drug accumulation. The utility of the new indices of accumulation is illustrated by reference to studies of gentamicin tissue uptake and its proposed relation to nephrotoxicity.
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Gonda, I., Harpur, E.S. Accumulation in the peripheral compartment of a linear two-compartment open model. Journal of Pharmacokinetics and Biopharmaceutics 8, 99–104 (1980). https://doi.org/10.1007/BF01059451
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DOI: https://doi.org/10.1007/BF01059451