Skip to main content
SpringerLink
Log in

Tuftsin analogs and their biological activity

  • Published:
Molecular and Cellular Biochemistry Aims and scope Submit manuscript

Summary

In this paper the literature data on the structure-activity relationship for the series of tuftsin analogs are summarized. Among others, the questions of the substitution of particular amino acid residues in different positions of the peptide chain, as well as the questions of shortening and lengthening of the peptide chain of tuftsin, are reviewed. The existing models of the biologically active conformation of tuftsin are also summarized.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Najjar, V. A., 1974. Adv. Enzymology 41: 129–178.

    Google Scholar 

  2. Nishioka, K., Constantopoulos, A., Satoh, P. S., Mitchell, M. V. & Najjar, V. A., 1973. Biochim. Biophys. Acta 310: 217–229.

    Google Scholar 

  3. Nishioka, K., Satoh, P. S., Constantopoulos, A. & Najjar, V. A., 1973. Biochim. Biophys. Acta 310: 230–237.

    Google Scholar 

  4. Najjar, V. A., Chaudhuri, M. K., Konopinska, D., Beck, B. B., Layne, P. P. & Linehan, L., 1981. Augmenting Agents in Cancer Therapy (Hersh, E. M., Chirigos, M. A. & Mastrangelo, M., eds.), 459–478, Raven Press, New York.

  5. Najjar, V. A., 1978. Exp. Cell Biol. 46: 114–126.

    Google Scholar 

  6. Najjar, V. A., 1970. Ger. Offen., 2, 123, 003, US Appl. 98, 860.

  7. Najjar, V. A., 1980. Macrophages and Lymphocytes, (Escobar, M. R. & Friedman, M., eds.), part A, pp. 131–147, Plenum Publ. Corp.

  8. Konopińska, D., Nawrocka, E., Siemion, 1. Z., Szymaniec, S. & Slopek, S., 1976. Peptides 1976, Proc. 14th Europ. Pept. Symp., Wepion 1976. (Loffet, A. ed.), pp. 535–539, Ed. de l'Universite de Bruxelles, Bruxelles.

  9. Konopińska, D., Nawrocka, E., Siemion, I. Z., Slopek, S., Szymaniec, S. & Klonowska, E., 1977. Int. J. Pept. Prot. Res. 9: 71–77.

    Google Scholar 

  10. Martinez J., Winternitz, T. & Vindel, J., 1977. Eur. J. med. Chem. - Chimica Therapeutica 12: 511–516.

    Google Scholar 

  11. Fridkin, M., Stabinsky, Y., Zakuth, V. & Spirer, Z., 1976. Peptides 1976, Proc. 14th Europ. Pept. Symp., Wepion 1976 (Loffet, A. ed.), pp. 541–550, Ed. de l'Université de Bruxelles, Bruxelles.

  12. Fridkin, M., Stabinsky, Y., Zakuth, V. & Spirer, Z., 1977. Biochim. Biophys. Acta 496: 203–211.

    Google Scholar 

  13. Yajima, H., Ogawa, H., Watanabe, H., Fuji, N., Kurobe, M. & Miamoto, S., 1975. Chem. Pharm. Bull., 371–374.

  14. Vicar, J., Gut, V., Frić L. & Blaha, K., 1976. Coll. Czechoslov. Chem. Commun. 41: 3467–3473.

    Google Scholar 

  15. Najjar, V. A., 1979. Klin. Wochenschr. 57: 751–756.

    Google Scholar 

  16. Herman, Z. S., Plech, A., Stachura, S., Siemiop, I. Z. & Nawrocka, E., 1981. Experientia, 37: 76–77.

    Google Scholar 

  17. Constantopoulos, A. & Najjar, V. A., 1973. J. Biol. Chem. 248: 3819–3822.

    Google Scholar 

  18. Spirer, Z., Zakuth, V., Bogair, N. & Fridkin, M., 1977. Eur. J. Immunol. 7: 69–74.

    Google Scholar 

  19. Koenig, W. & Seiler, F. R., 1975. Ger. Often. 2, 343, 034; Chem. Abs. 83: 10892v.

  20. Konopinska, D., Siemion, I. Z., Szymaniec, S. & Slopek, S., 1979. Polish J. Chem. 53: 343–351.

    Google Scholar 

  21. Stabinsky, Y., Gottlieb, P. D. & Fridkin, M., in press.

  22. Edelman, G. M., Cunningham, B. A., Gall, W. E., Gottlieb, P. D. & Rutinshawaxdol, M. J., 1969. Proc. Natl. Acad. Sci. USA 63: 78–85.

    Google Scholar 

  23. Konopinska, D., 1978. Polish J. Chem. 52: 953–957.

    Google Scholar 

  24. Nair, R. M. G., Ponce, B. & Fudenberg, H. H., 1978. Immunochemistry 15: 901–907.

    Google Scholar 

  25. Yasumura, K., Okamoto, K. & Shimamura, S., 1977. Yakugaku Zasshi 97: 324–329.

    Google Scholar 

  26. Kopple, K. D., Go, A. & Pilipauskas, D. R., 1975. J. Am. Chem. Soc. 97: 6830–6838.

    Google Scholar 

  27. Zimmerman, S. S. & Scheraga, H. A., 1977. Biopolymers 16: 811–843.

    Google Scholar 

  28. Nawrocka, E., Siemion, I. Z., Slopek, S. & Szymaniec, S., 1980. Int. J. Pept. Prot. Res., 16: 200–207.

    Google Scholar 

  29. Venkatachalam, C. M., 1968. Biopolymers 6: 1425–1436.

    Google Scholar 

  30. Ovchinnikov, Yu. A., 1973. Peptides 1972, Proc. 12th Europ. Pept. Symp. (Hanson, H. & Jakubke, H. D. eds.) p. 10, North-Holland Publ. Co., Amsterdam.

  31. Chou, P. Y. Fasman, G. D., 1977. J. Mol. Biol. 115: 135–175.

    Google Scholar 

  32. Hodes, Z. I., Nemethy G. & Scheraga, H. A., 1979. Biopolymers 18: 1611–1634.

    Google Scholar 

  33. Sucharda-Sobczyk, A., Siemion, I. Z. & Konopińska, D., 1979. Europ. J. Biochem. 96: 131–139.

    Google Scholar 

  34. Chandrasekaran, R., Lakshminarayan, A. V., Pandya, U. V. & Ramachandran, G. N., 1973. Biochim. Biophys. Acta 303: 14–27.

    Google Scholar 

  35. Sucharda-Sobczyk, A., Siemion, I. Z. & Nawrocka, E., 1980, Acta Biochim Pol 27: 353–363.

    Google Scholar 

  36. Siemion, I. Z., Lisowski, M., Konopinska, D. & Nawrocka, E., 1980. Eur. J. Biochem., 112: 339–343.

    Google Scholar 

  37. Grathwohl, Ch. & Wuthrich, K., 1976. Biopolymers 15: 2025–2041.

    Google Scholar 

  38. Deslauriers, R., Becker, J. M., Steinfeld, A. S. & Naider, F., 1979. Biopolymers 18: 523–538.

    Google Scholar 

  39. Blumenstein, M., Layne, P. P. & Najjar, V. A., 1979. Biochemistry 18: 5247–5253.

    Google Scholar 

  40. Sekacis, I. P., Lyepintch, E. E., Veretennikova, N. J. & Chipens, G. J., 1979. Bioorg. Kim. (russ.) 5: 1617–1622.

    Google Scholar 

  41. Bystrov, V. F., Ivanov, V. T., Portnova, S. L., Balashova, T. A. & Ovchinnikov, Yu. A., 1973. Tetrahedron 29: 873–876.

    Google Scholar 

  42. Nikoforovich, G. V., 1978. Bioorg. Khim. (russ.) 4: 1427–1430.

    Google Scholar 

  43. Konopińska, D., Nawrocka, E., Siemion, I. Z., Szymaniec, S. & Slopek, S., 1979. Arch. Immunol. Therap. Exper. 27: 151–157.

    Google Scholar 

  44. Hisatsune, K., Kobayashi, K., Nozaki, S. & Muramatsu, I., 1978. Chem. Pharm. Bull. 26: 1006–1007.

    Google Scholar 

  45. Stabinsky, Y., Fridkin, M., Zakuth, V. & Spirer, Y., 1979. Int. J. Pept. Prot. Res. 12: 130–138.

    Google Scholar 

  46. Fitzwater, S., Hodes, Z. I. & Scheraga, H. A., 1978. Macromolec. 11: 805–811.

    Google Scholar 

  47. Matsuura, S., Takasaki, A., Hiratani, H., Kotera, T. & Fujiwara, S., 1975. Jappan Kokai 75: 373; Chem. Abs. 83: 114937e.

    Google Scholar 

  48. Konopińska, D., Siemion, I. Z., Szymaniec, S. & Slopek, S., 1978. Polish J. Chem. 52: 573–580.

    Google Scholar 

  49. Konopińska, D., Siemion, I. Z. & Baros-Stuliglowa, E., 1978. Polish J. Chem. 52: 2255–2257.

    Google Scholar 

  50. Okamoto, K. & Shimamura, S., 1976. Yakugaku Zasshi 96: 315–320.

    Google Scholar 

  51. Yamanaka, N., Fukushima, M., Matsauka, H., Nishida, K. & Ota, K., 1979. Phagocytosis, pp. 93–100, Tokyo Press, Tokyo.

    Google Scholar 

  52. Kent, H. A., 1975. J. Biol. Reprod. 12: 504–509.

    Google Scholar 

  53. Chipens, G., Nikiforovich, G., Mutulis, F., Veretennikova, N., Vosekalna, L., Sosnov, A., Polevayz L., Ancans, J., Mishlakova, N., Liepinsh, E., Sekacis, I. & Breslav, M., 1979. Peptides, Structure and Biological Function, Proc. 6th American Pep. Symp. (Gross, E. & Meienhofer, Y., eds.), pp. 567–570, Pierce Chem. Comp.

Download references

Author information

Authors and Affiliations

  1. Institute of Chemistry, Wroclaw University, 50-383, Wroclaw, Poland

    Ignacy Z. Siemion & Danuta Konopinska

Authors
  1. Ignacy Z. Siemion
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Danuta Konopinska
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Siemion, I.Z., Konopinska, D. Tuftsin analogs and their biological activity. Mol Cell Biochem 41, 99–111 (1981). https://doi.org/10.1007/BF00225300

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00225300

Keywords

Search

Navigation