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Affective deficits and pain insensitivity in schizophrenia

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Abstract

Affective deficits have long been considered a prominent feature of schizophrenia and play a central role in recent theory and research on the pathophysiology of this disorder. However, it has recently been argued that current approaches to the conceptualization and assessment of affective flattening in schizophrenia are confounded by the social and neuromotor deficits that are also prevalent in this disorder. Insensitivity to pain in individuals with schizophrenia — a phenomenon that has been reported frequently but never systematically investigated — provides one approach to examining affective flattening unconfounded by social and neuromotor deficits. Two studies are described in which signal detection theory measures of thermal pain sensitivity were examined in patients with schizophrenia, mood disorder, and normal controls; in addition, in the patients with schizophrenia, the relationships between these measures and measures of affective deficits were examined. Patients with schizophrenia had significantly poorer sensory discrimination of painful thermal stimuli than control subjects, but did not differ from controls with respect to their response criterion for reports of pain; patients with mood disorder had a significantly higher (i.e., more stoical) criterion for reports of pain than controls. As predicted, among the patients with schizophrenia, higher response criterion was significantly correlated with greater affective flattening and less intense affective experience (as well as with fewer positive symptoms and poorer premorbid adjustment). The results of these studies suggest that pain insensitivity in schizophrenia may reflect affective as well as sensory abnormalities, and that pain insensitivity in schizophrenia may provide a method for studying affective flattening in this disorder that is relatively independent of the social and neuromotor deficits that confound existing measures of this symptom. Continued examination of the relationship between pain insensitivity and affective deficits in schizophrenia is also important because numerous clinical reports have suggested that pain insensitivity is detrimental to health and can have life-threatening consequences in individuals with this disorder.

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Authors and Affiliations

  1. Columbia University, USA

    Robert H. Dowrkin Ph.D., Lewis A. Opler & Stephanie R. White

  2. Columbia University and New York State Psychiatric Institute, USA

    W. Crawford Clark

  3. New York State Psychiatric Institute, USA

    Joshua D. Lipsitz

  4. Columbia University and New York State Psychiatric Institute, USA

    Xavier F. Amador, Charles A. Kaufmann & Jack M. Gorman

Authors
  1. Robert H. Dowrkin Ph.D.
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  2. W. Crawford Clark
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  3. Joshua D. Lipsitz
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  4. Xavier F. Amador
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  5. Charles A. Kaufmann
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  6. Lewis A. Opler
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  7. Stephanie R. White
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  8. Jack M. Gorman
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Additional information

This research was supported, in part, by research grants from the National Institute of Neurological Disorders and Stroke to Robert H. Dworkin (NS-30714) and W. Crawford Clark (NS-09263, NS-20248).

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Dowrkin, R.H., Crawford Clark, W., Lipsitz, J.D. et al. Affective deficits and pain insensitivity in schizophrenia. Motiv Emot 17, 245–276 (1993). https://doi.org/10.1007/BF00992222

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