Skip to main content
Log in

Structural Requirements for Interaction with the Oligopeptide Transporter in Caco-2 Cells

  • Note
  • Published:
Pharmaceutical Research Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

REFERENCES

  1. C. H. Gochoco, F. M. Ryan, J. Miller, P. L. Smith, and I. J. Hidalgo. Uptake and transepithelial transport of the orally adsorbed cephalosporin cephalexin, in the human intestinal cell line, Caco-2. Int. J. Pharm. 104:187–202 (1994).

    Google Scholar 

  2. D. M. Matthews and S. A. Adibi. Peptide absorption. Gastroenterology. 71:151–161 (1976).

    Google Scholar 

  3. V. Ganapathy and F. H. Leibach. Is intestinal peptide transport energized by a proton gradient? Am. J. Physiol. 249:G153–G160 (1985).

    Google Scholar 

  4. I. J. Hidalgo, F. M. Ryan, G. J. Marks, and P. L. Smith. pH-dependent transepithelial transport of cephalexin in rabbit intestinal mucosa. Int. J. Pharm. 98:83–92 (1993).

    Google Scholar 

  5. A. H. Dantzig and L. Bergin. Carrier-mediated uptake of cephalexin in human intestinal cells. Biochem. Biophys. Res. Commun. 155:1082–1087 (1988).

    Google Scholar 

  6. D. T. Thwaites, B. H. Hirst, and N. L. Simmons. Direct assessment of dipeptide/H+ symport in intact human intestinal (Caco-2) epithelium: A novel method utilising continuous intracellular pH measurement. Biochem. Biophys. Res. Commun. 194:432–438 (1993).

    Google Scholar 

  7. P. W. Swaan, M. C. Stehouwer, R. I. C. Blok, and J. J. Tukker. Prodrug approach using the intestinal peptide carrier. Pharm. Res. 10:S-295 (1993).

    Google Scholar 

  8. M. Hu, P. Subramanian, H. I. Mosberg, and G. L. Amidon. Use of the peptide carrier system to improve the intestinal absorption of L-α-methyldopa: Carrier kinetics, intestinal permeabilities, and in vitro hydrolysis of dipeptidyl derivatives of L-α-methyldopa. Pharm. Res. 6:66–70 (1989).

    Google Scholar 

  9. M. Hu and R. T. Borchardt. Transport of a large neutral amino acid in a human intestinal epithelial cell line (Caco-2): Uptake and efflux of phenylalanine. Biochim. Biophys. Acta. 1135:233–244 (1992).

    Google Scholar 

  10. A. Blais, P. Bissonnette, and A. Berteloot. Common characteristics for Na+-dependent sugar transport in Caco-2 cells and human fetal colon. J. Membrane Biol. 99:113–125 (1987).

    Google Scholar 

  11. R. Wootton and R. Hazelwood. Relative affinity of a series of charged dipeptides for the peptide carrier of rabbit intestinal brush-border membranes. Biochem. Soc. Trans. 17:691–692 (1989).

    Google Scholar 

  12. E. P. Eddy, C. Wood, J. Miller, G. Wilson and I. J. Hidalgo. A comparison of the affinities of dipeptides and antibiotics for the di-/tripeptide transporter in Caco-2 cells. Int. J. Pharmacol., In Press (1994).

  13. A. H. Dantzig and L. Bergin. Uptake of the cephalosporin, cephalexin, by a dipeptide transport carrier in the human intestinal cell line, Caco-2. Biochim. Biophys. Acta. 1027:211–217 (1990).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hidalgo, I.J., Bhatnagar, P., Lee, CP. et al. Structural Requirements for Interaction with the Oligopeptide Transporter in Caco-2 Cells. Pharm Res 12, 317–319 (1995). https://doi.org/10.1023/A:1016259816661

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1016259816661

Navigation