Abstract
The 12 known connexin genes coding for the subunit proteins of the gap junction channels and related in nucleotide sequence are widely dispersed in the mouse genome. By using a series of mouse × Chinese hamster somatic cell hybrids and molecular probes of murine connexin genes, we have assigned the connexin 50 gene to mouse chromosome 3. The connexin 33 gene has been mapped to the X chromosome, thus confirming the previous chromosomal assignment of this gene based on interspecific back-cross mapping.
Literature Cited
Dermietzel, R., and Spray, D.C. (1993).Trends Neurosci. 16:186–192.
Milks, L.C., Kumar, N.M., Houghten, R., Unwin, N., and Gilula, N.B. (1988).EMBO J:7:2967–2975.
Bennett, M.V.L., Barrio, L., Bargiello, T.A., Spray, D.C., Hertzberg, E.L., and Saez, J. (1991).Neuron 6:305–320.
Willecke, K., Hennemann, H., Dahl, E., Jungbluth, S., and Heynkes, R. (1991).Eur. J. Cell Biol. 56:1–7.
White, T.W., Bruzzone, R., Goodenough, D.A., and Paul, D.L. (1992),Mol. Biol.: Cell 3:711–720.
Haefliger, J.A., Bruzzone, R., Jenkins, N.A. Gilbert, D.J., Copeland, N.G., and Paul, D.L. (1992).J. Biol. Chem. 267:2057–2064.
Bruzzone, R., Haefliger, J.A., Gimlich, R.L., and Paul, D.L. (1993).Mol. Biol. Cell 4:1–5.
Willecke, K., Jungbluth, S., Dahl, E., Hennemann, H., Heynkes, R., and Grzeschik, K.H. (1990).Eur. J. Cell Biol. 53:275–280.
Schwarz, H.J., Chang, Y.S., Hennemann, H., Dahl, E., Lalley, P.A., and Willecke, K. (1992).Somat. Cell Mol. Genet. 18:351–359.
Hennemann, H., Dahl, E., White, J.B., Schwarz, H.J., Chang, Y.S., Lalley, P.A., Nicholson, B.J., and Willecke, K. (1992).J. Biol. Chem. 267:17225–17233.
Hsieh, C.L., Kumar, N.M., Gilula, N.B., and Francke, U. (1991).Somat. Cell Mol. Genet. 17:191–200.
Fishman, G.I., Eddy, R.L., Shows, T.B., Rosenthal, L., and Leinwand, L.A. (1991)Genomics 10:250–256.
Corcos, I.A., Lafreniere, R.G., Begy, C.R., Loch-Caruso, R., Willard, H.F., and Glover, T.W. (1992).Genomics 13:479–480.
Raimondi, E., Gaudi, S., Moralli, D., De Carli, L., Malcovati, M., Simonic, T., and Tenchini, M.L. (1992).Cytogenet. Cell Genet. 60:210–211.
Bergoffen, J., Chen, K., Nieuwenhuijsen, B.W., Cochrane, S., Fairweather, N., Monaco, A., Haites, N., and Fischbeck, K.H. (1993).Am. J. Hum. Genet. 53 (suppl.):977 (abstract).
Fairweather, N., Bell, C., Cochrane, S., Chelly, J., Wang, S., Mostacciuolo, M.L., Monaco, A.P., and Haites, N.E. (1994).Hum. Mol. Genet. 3:29–34.
Bergoffen, J., Scherer, S.S., Wang, S., Oronzi Scott, M., Bone, L.J., Paul, D.L., Chen, K., Lensch, M.W., Chance, P.F. and Fischbeck, K.H. (1993).Science 262:2039–2042.
Green, M.C. (1989). InGenetic Variants and Strains of the Laboratory Mouse, 2nd ed., (eds.), Lyon, M.F., and Searle, A.G. (Oxford University Press, New York), pp. 12–403.
Sambrook, J., Fritsch, E.F., and Maniatis, T. (1989).Molecular Cloning A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Schwarz, HJ., Chang, Y.S., Lalley, P.A. et al. Chromosomal assignments of mouse genes for connexin 50 and connexin 33 by somatic cell hybridization. Somat Cell Mol Genet 20, 243–247 (1994). https://doi.org/10.1007/BF02254763
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02254763