Abstract
A genetic technique has been developed for isolating nuclear hybrids which are products of fusion between karyoplasts and whole cells. Nuclear hybrids have a greatly reduced mitochondrial component obtained from the nuclear donor and exhibit differences when compared to the corresponding whole-cell hybrids, such as better long-term survival and accelerated chromosome segregation. These results suggest that divergent mitochondria in a cell-fusion product may have adverse effects on survival.
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Weide, L.G., Clark, M.A., Rupert, C.S. et al. Detrimental effect of mitochondria on hybrid cell survival. Somat Cell Mol Genet 8, 15–21 (1982). https://doi.org/10.1007/BF01538647
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DOI: https://doi.org/10.1007/BF01538647