Zusammenfassung
Durch die Infusion von Propranolol kommt es beim Menschen zu einer Senkung der Konzentration der freien Fettsäuren, zu einer signifikanten Erniedrigung der Umsatzrate der freien Fettsäuren und einer signifikanten Erniedrigung der „Fractional turnover rate“ der freien Fettsäuren im Plasma. Die Bildung der endogenen Plasmatriglyceride aus freien Fettsäuren wird signifikant erniedrigt.
Es ist anzunehmen, daß die Wirkung von Propranolol auf den Stoffwechsel der freien Fettsäuren auf einer Blockierung der endogenen Katecholaminwirkung beruht.
Alle Wirkungen von Propranolol auf den Fettsäurestoffwechsel lassen sich kausal auf eine Hemmung der Lipolyse im Fettgewebe zurückführen.
Summary
The infusion of propranolol, aβ-blocking agent, results in a decrease in the concentration of free fatty acids, a significant lowering of the turnover rate of free acids, and a significant decrease of the fractional turnover rate of free fatty acids in plasma.
The esterification rate of free fatty acids to plasma triglycerides is significantly reduced.
It is suggested that the action of propranolol on the metabolism of free fatty acids is based on the blockage of the action of endogenous catecholamines. The observed actions of propranolol on the metabolism of free fatty acids are considered to result from the inhibition of lipolysis in the adipose tissue.
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Sailer, S., Sandhofer, F., Bolzano, K. et al. Über die Wirkung eines β-Blockers (Propranolol) auf den Umsatz der freien Fettsäuren und den Einbau von freien Fettsäuren in Plasmatriglyceride beim Menschen. Klin Wochenschr 45, 670–674 (1967). https://doi.org/10.1007/BF01747198
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DOI: https://doi.org/10.1007/BF01747198