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Einfluß der glomerulären Filtrationsrate auf die tubuläre Glucosereabsorption bei Kindern

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Zusammenfassung

An 10 Kindern im Alter von 14 Tagen bis zu 6 1/2 Jahren wurde der Einfluß der glomerulären Filtrationsrate (GFR) auf die maximale tubuläre Glucosereabsorption (TmG) untersucht. Dabei fanden wir, in Übereinstimmung mit den tierexperimentellen Befunden anderer Autoren, eine lineare Korrelation zwischen GFR und TmG. Änderungen des GFR haben eine proportionale Änderung des Tm G zur Folge. Die Ursache dieser Korrelation ist noch unklar. Mikroperfusionsuntersuchungen am Einzelnephron der Ratte lassen vermuten, daß sie auf einer Änderung der Lumenweite des proximalen Tubulus beruht.

Der Quotient GFR/TmG — Ausdruck des glomerulären-tubulären Gleichgewichts — ist größer als bei Erwachsenen und altersabhängig: je jünger das Kind, desto größer der Quotient. Es wird angenommen, daß der in den ersten Lebensmonaten, im Vergleich zum Glomerulum, noch sehr kleine proximale Tubulus die Ursache für diese Altersabhängigkeit ist.

Summary

Glomerular filtration rates (GFR) and maximum tubular reabsorption of glucose (TmG) were determined in 10 infants and children aged 14 days to 6 1/2 years. In agreement with experiments performed on animals by other authors we found a linear correlation between GFR and TmG. Changes in the GFR result in a proportional alteration of TmG. The cause for this correlation is unknown. Experiments using the microperfusion method on single rat nephrons indicate, that this correlation can be attributed to a change in the internal diameter of the proximal tubule.

The ratio GFR/TmG — expressing the glomerulartubular balance — is higher than in adults and dependent on the age of the infant: the younger the child, the higher is the ratio. During the first month of life the size of the proximale tubule is relatively short in comparison for the glomerulum. We suppose that this is the cause for age dependence of the ratio.

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Authors and Affiliations

  1. Kinderklinik der Universität Würzburg, Germany

    D. Gekle

  2. Institut für Mutter und Kind, Prag-Podoli

    M. Janovský & R. Šlechtová

  3. Physiologisches Institut der Akademie der Wissenschaften, Prag-Krč

    J. Martinek

Authors
  1. D. Gekle
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  2. M. Janovský
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  3. R. Šlechtová
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  4. J. Martinek
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Additional information

Herrn Prof. Dr. med.J. Svejcar, Prag, zu seinem 70. Geburtstag in Verehrung gewidmet.

Technische AssistenzR. Boučková

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Gekle, D., Janovský, M., Šlechtová, R. et al. Einfluß der glomerulären Filtrationsrate auf die tubuläre Glucosereabsorption bei Kindern. Klin Wochenschr 45, 416–419 (1967). https://doi.org/10.1007/BF01728415

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