Zusammenfassung
Menschliches und bovines Plasma und Serum wurden an Sephadex G 200 aufsteigend chromatographiert und in den Fraktionen die Faktor X-Aktivität bestimmt. Faktor X aus Plasma wurde in allen Fällen schneller aus der Säule eluiert als der gleiche Faktor aus Serum. Aus diesem Befund kann auf eine während der Blutgerinnung aufgetretene Molekülverkleinerung des Proteins geschlossen werden, welches die Faktor X-Aktivität trägt.
Summary
After fractional chromatography of human and bovine plasma as well as serum, employing a spehadex G 200 column, activity of factor X was determined in the different aliquots. In the column factor X was eluated faster from plasma than from serum. From this finding one can conclude that the molecule carrying factor X activity becomes smaller during the coagulation process.
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Heller, A., Rasche, H. & Hiemeyer, V. Hinweis auf eine Moleküländerung des Faktors X bei der Blutgerinnung. Klin Wochenschr 48, 125–126 (1970). https://doi.org/10.1007/BF01484629
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DOI: https://doi.org/10.1007/BF01484629