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Der Tryptophan-Stoffwechsel bei der progressiven Sklerodermie

Tryptophan-load in progressive scleroderma

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Summary

This presentation describes effects of oral tryptophan loading (5.0 g DL) on tryptophan metabolism in healthy subjects (n=10) and persons with progressive scleroderma. N1-methylnicotinamide (N1MN), 3-hydroxyanthranilic acid (3 HAA), kynurine (KN), tryptamin (TA), xantheurenic acid (XA) were determinated. Alterations of tryptophan metabolism were evaluated by 24 h urinary excretions of the following metabolites: 5-hydroxy indolacetic acid (5 HAA) and indole-3-acetic acid (IAA). The pathological pathways were discussed, especially the way and influence of serotonine.

Zusammenfassung

An einem Krankengut der progressiven Sklerodermie (n=11) gegenüber Kontrollen (n=10) wurden im 24 h-Urin vor, unter und nach der Belastung mit 5 g DL-Tryptophan 7 Metaboliten des Tryptophanabbaues (Kynurenin, 3-Hydroxyanthranilsäure, Xanthurensäure, 5-Hydroxyindolessigsäure, Indol-3-Essigsäure, N-Methylnicotinamid, Tryptamin) quantitativ bestimmt. Die 24 h-Ausscheidungen von 5-Hydroxyindolessigsäure und Indol-3-Essigsäure waren gegenüber dem Kontrollkollektiv signifikant erhöht. Ein Rückgang der Ausscheidung von 5-Hydroxyindolessigsäure nach Belastung bei Kontrollen deutet die Möglichkeit einer autonomen Regulation des Serotoninstoffwechsels sowie eine Störung der Regulation bei Sklerodermiepatienten an. Ein Versuch, unsere Ergebnisse denen bisher dem Schrifttum vorliegenden Untersuchungsbefunden gegenüberzustellen, ist aus methodentechnischen Gründen nicht durchführbar gewesen.

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  1. Universitäts-Hautklinik, Hamburg-Eppendorf

    H. W. Kreysel, K. Meyerhoff & J. Kimmig

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Kreysel, H.W., Meyerhoff, K. & Kimmig, J. Der Tryptophan-Stoffwechsel bei der progressiven Sklerodermie. Klin Wochenschr 54, 881–887 (1976). https://doi.org/10.1007/BF01483590

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