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Perhexiline induces generalized lipidosis in rats

Perhexilin verursacht bei der Ratte eine generalisierte Lipidose

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Zusammenfassung

Perhexilin (Pexid®) verursacht bei der Ratte das generalisierte Auftreten von lamellären und kristalloiden zytoplasmatischen Einschlußkörpern, die denjenigen gleichen, die bei Patienten mit Perhexilin-induzierter Polyneuropathie beschrieben worden sind. Aus den vorgelegten Befunden wird geschlossen, daß Perhexilin, eine amphiphile kationische Verbindung, ein starker Induktor einer generalisierten Lipidose ist.

Summary

Administration of perhexiline (Pexide®) to rats causes generalized occurrence of lamellated and crystalloid cytoplasmic inclusions which resemble those described in patients with perhexiline-induced polyneuropathy. It is concluded that perhexiline being an amphiphilic cationic compound is a potent inducer of generalized lipidosis.

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Authors and Affiliations

  1. Department of Pharmacology and Department of Anatomy, University of Kiel, Germany

    Heinz Lüllmann & Renate Lüllmann-Rauch

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  1. Heinz Lüllmann
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  2. Renate Lüllmann-Rauch
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Lüllmann, H., Lüllmann-Rauch, R. Perhexiline induces generalized lipidosis in rats. Klin Wochenschr 56, 309–310 (1978). https://doi.org/10.1007/BF01489178

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  • DOI: https://doi.org/10.1007/BF01489178

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