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Formation and action of prostaglandins in the kidney

Synthese und Wirkungen von Prostaglandinen in der Niere

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Zusammenfassung

Die Niere hat eine hohe Synthesekapazität für ein Spektrum verschieden wirkender Prostaglandine (PG). In vivo und in vitro Untersuchungen haben gezeigt, daß die renale Bildung von PG's, möglicherweise in Gefäßen der Nierenrinde, einen wichtigen Teil der verschiedenen Mechanismen für die Reninsekretion darstellt. In der Nierenrinde gebildete PG's scheinen auch an der Einstellung des renalen Gefäßwiderstandes und des Glomerulumfiltrats beteiligt zu sein. Im Nierenmark produziertes PGE2 moduliert die hydroosmotische Wirkung des antidiuretischen Hormons und beeinflußt so die Konzentrierungsfähigkeit der Niere. Hohe NaCl-Aufnahme vermindert und niedrige NaCl-Zufuhr sowie Hypokaliämie steigern die renale PG-Synthese. Diese Eigenschaften machen wahrscheinlich, daß renale PG's sowohl bei der Regulation der Elekrolyt- und Wasserbilanz als auch bei der Blutdruckkontrolle beteiligt sind. Wegen der engen Wechselwirkung mit dem Renin-Angiotensin-System könnten Veränderungen der renalen PG-Bildung eine Rolle bei Erkrankungen spielen, die mit erhöhten oder erniedrigten Reninspiegeln einhergehen. So könnte z.B. eine gestörte renal-kortikale Bildung vasodilatierender PG's sowohl für die verminderte Stimulierbarkeit der Reninsekretion als auch für den gesteigerten renalen Gefäßwiderstand bei essentieller Hypertonie mit verantwortlich sein.

Summary

The kidney has a high capacity to produce a spectrum of different acting prostaglandins (PG). In vivo and in vitro studies have shown that renal formation of PG's, possibly in the vasculature of the cortex represents an essential step in the mechanisms regulating the secretion of renin. PG's formed in the cortex seem to participate also in the control of renal vascular resistance and glomerular filtration rate. PGE2 formed in the medulla modulates the hydroosmotic action of antidiuretic hormone and influences the kidney's capacity for urine concentratron. Renal PG formation is reduced by high NaCl intake and enhanced by low NaCl intake and in hypokalemic states. These findings make renal PG's good candidates for participation in the regulation of salt and water balance and in the control of blood pressure. Due to the close connection with the renin angiotensin system, alterations in renal PG formation might be involved in the etiology of high and low renin states. Thus, an impairment in the renal cortical production of vasodilating and renin-stimulating PG's could constitute the common denominator for both the reduced renin secretion and the increased vascular resistance which have been reported to be associated in essential hypertension.

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Authors and Affiliations

  1. Medizinische Klinik Innenstadt, der Universität München, Ziemssenstr. 1, D-8000, München 2, Germany

    P. C. Weber, B. Scherer, W. Siess, E. Held & J. Schnermann

  2. Physiologisches Institut, der Universität München, Germany

    J. Schnermann

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  1. P. C. Weber
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  4. E. Held
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Weber, P.C., Scherer, B., Siess, W. et al. Formation and action of prostaglandins in the kidney. Klin Wochenschr 57, 1021–1029 (1979). https://doi.org/10.1007/BF01479987

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