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Die T3-Hyperthyreose unter den Aspekten der Sekretion und peripheren Produktion der Schilddrüsenhormone

T3-hyperthyroidism under the aspects of secretion and peripheral production of thyroid hormones

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Summary

In contrast to T4/T3-hyperthyroidism, where T4, T3, and r-T3 serum concentrations (SC) are elevated, in T3-hyperthyroidism the T3-SC alone is increased, whereas T4-SC is normal and r-T3 may be decreased. Endogenous labelling of T4 with131I is increased in T3-hyperthyroidism similarly as in T4/T3-hyperthyroidism, clearly reflecting an increased thyroidal formation of T4 in T3-hyperthyroidism. The contradiction of a normal SC of T4 in the presence of enhanced thyroidal formation of T4 may be explained by increased peripheral T4-deiodination. Since in T3-hyperthyroidism T3-SC are elevated whereas r-T3-SC are decreased, there is good evidence for a shift in T4 conversion.

Zusammenfassung

Bei der T3-Hyperthyreose ist im Vergleich zu der T4/T3-Hyperthyreose nur das T3 erhöht, während das T4 und das r-T3 im Normbereich liegen. Die endogene Markierung des T4 ist auch bei der T3-Hyperthyreose erhöht, so daß eine vermehrte T4-Sekretion angenommen werden muß. Die normalen T4-Konzentrationen dürften aus einer verstärkten T4-Dejodination resultieren. Als Ursache für das hohe T3 bei gleichzeitig normalem r-T3 wird eine Richtungsumkehr der Dejodination des T4 zum T3 zu ungunsten des r-T3 diskutiert.

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Authors and Affiliations

  1. Abteilung für Innere Medizin I, Universität Ulm, Germany

    U. Loos, F. Konrad & E. F. Pfeiffer

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  1. U. Loos
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  2. F. Konrad
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  3. E. F. Pfeiffer
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Mit Unterstützung durch die Deutsche Forschungsgemeinschaft (SFB87/B6 und H1)

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Loos, U., Konrad, F. & Pfeiffer, E.F. Die T3-Hyperthyreose unter den Aspekten der Sekretion und peripheren Produktion der Schilddrüsenhormone. Klin Wochenschr 59, 495–500 (1981). https://doi.org/10.1007/BF01696211

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  • DOI: https://doi.org/10.1007/BF01696211

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