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Immunpharmakologie der Kortikosteroide

Immunopharmacology of the corticosteroids

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Summary

Immunopharmacological effects of corticosteroids are primarily dependent upon their capacity to modify inflammatory reactions at various levels. Their molecular effects are related to the vascular system and to lymphocytes, phagocytes and mast cells, all cell types being involved in inflammation. They modulate the physiology, molecular biology and membrane dynamics of these cells thereby influencing cellular and humoral immune functions. The complexity of these effects may at least partially explain the usefulness of corticosteroids in cases of immunoproliferative, autoimmune and allergic disorders.

Zusammenfassung

Die immunpharmakologische Wirkung von Kortikosteroiden besteht primär in der Beeinflussung von Entzündungsreaktionen auf verschiedenen Ebenen. Ihre molekularen Effekte betreffen hierbei das Gefäßsystem sowie die in die Entzündungsreaktionen involvierten Lymphozyten, Phagozyten und Mastzellen. Sie modulieren die Zellphysiologie, Molekularbiologie und Membrandynamik dieser Zellen und beeinflussen dabei zelluläre und humorale Immunmechanismen. Die Komplexität dieser Wirkung erklärt zumindest teilweise den Nutzen einer Kortikosteroidtherapie bei immunproliferativen, autoimmunologischen und allergischen Erkrankungen.

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Abbreviations

DTH:

delayed type hypersensitivity

BCG:

Bazillus Calmette-Guerin

RES:

Retikuloendotheliales System

HLA:

Human leukocyte antigen

DNS:

Desoxyribonukleinsäure

RNS:

Ribonukleinsäure

SRS-A:

Slow reacting substance of anaphylaxis

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Authors and Affiliations

  1. Department für Innere Medizin, Universitätsspital Zürich, Switzerland

    L. H. Block, W. Vetter & W. Siegenthaler

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  1. L. H. Block
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  2. W. Vetter
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  3. W. Siegenthaler
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Block, L.H., Vetter, W. & Siegenthaler, W. Immunpharmakologie der Kortikosteroide. Klin Wochenschr 60, 1373–1384 (1982). https://doi.org/10.1007/BF01716242

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  • DOI: https://doi.org/10.1007/BF01716242

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