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Interdigestive motilin secretion and gallstone disease

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Summary

Plasma motilin concentrations were measured in eight controls and 11 patients with radiolucent gallstones over a period of 3–4 h following an overnight fast. In five of these patients the interdigestive motor complex (IDMC) was studied simultaneously. The results indicate: a) cyclical changes of plasma motilin concentrations (mean cycle duration 110±9.9 and 102±8.4 min,\(\bar x\)±SEM) and a significant correlation between the basal intercyclical motilin concentrations and the age (p<0.02) in the controls and the gallstone patients studied, and b) a significant correlation between the maximal motilin increase and the age in the controls (p<0.01) but not in the gallstone patients. The results therefore suggest a different behaviour of the interdigestive motilin patterns in controls and gallstone patients. As the motilin cycles were accompanied in 90% with an IDMC in the five patients studied this conclusion might include an abnormal interdigestive motor activity within the intestinal tract in gallstone patients.

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Authors and Affiliations

  1. Med. Kernklinik Poliklinik d. Univ., Martinistr. 52, D-2000, Hamburg 20, Federal Republic of Germany

    R. Klapdor MD & E. Hammer

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  1. R. Klapdor MD
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  2. E. Hammer
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Klapdor, R., Hammer, E. Interdigestive motilin secretion and gallstone disease. Klin Wochenschr 61, 251–253 (1983). https://doi.org/10.1007/BF01496131

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  • DOI: https://doi.org/10.1007/BF01496131

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