Summary
Treatment of normal adult rats with pyridoxine or a B-vitamin mixture resembling Neurobion® 1 led to an increase in serotonin content of various brain areas and to a decrease in the number of serotonin S2 receptors. The results indicate that the pyridoxal phosphate level in regions of the brain regulates the extent of decarboxylation of 5-hydroxytryptophan, the precursor of serotonin. The results also suggest a continuum from deficiency in pyridoxine to treatment of animals with a moderate excess of pyridoxine which is reflected in the synthesis and secretion into the synaptic cleft of the neurotransmitter serotonin.
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Dakshinamurti, K., Sharma, S.K. & Bonke, D. Influence of B vitamins on binding properties of serotonin receptors in the CNS of rats. Klin Wochenschr 68, 142–145 (1990). https://doi.org/10.1007/BF01646863
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DOI: https://doi.org/10.1007/BF01646863