Summary
Concentrations of immunoreactive insulin activity and of blood glucose were measured in portal and peripheral venous blood in six conscious dogs after oral administration of 1.0 g/kg glucose. Portal venous samples were obtained either by chronic catheterization or by direct puncture of the portal vein through a London-cannula. Portal venous IRI was already significantly increased 5 min after the onset of the stimulus. Peripheral venous IRI pattern reflected this early increase, but the peripheral venous blood glucose level was unchanged. The results indicate that the early peripheral venous IRI increase reflects a pancreatic insulin secretory reflex.
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Carlson, L.A., Kaijser, J., Rossner, S., Wahlquist, M.L., Wide, L.: Changes in insulin immunoreactivity across the circulation in man during infusion of glucose and a fat emulsion. Eur. J. Clin. Invest.5, 57–62 (1975)
Ferner, H.: Das hyperglykämisierende Prinzip des Pankreas, sowie über Gefäßverhältnisse und Innervation der Insel. Acta Neurovegetat.9, 47–60 (1954)
Fischer, U., Hommel, H., Fiedler, H., Bibergeil, H.: Reflex mechanism on insulin secretion. Endocrinol. Exp. (Bratisl.)8, 137–146 (1974)
Fischer, U., Hommel, H., Ziegler, M., Michael, R.: The mechanism of insulin secretion after oral glucose administration. I. Multiphasic course of insulin mobilization after oral administration of glucose in conscious dogs. Differences to the behaviour after intravenous administration. Diabetologia8, 104–110 (1972)
Fischer, U., Hommel, H., Ziegler, M., Jutzi, E.: The mechanism of insulin secretion after oral glucose administration. III. Investigations on the mechanism of a reflectoric insulin mobilization after oral stimulation. Diabetologia8, 385–390 (1972)
Fischer, U., Hommel, H., Nowak, W., Sill, U., Lippert, H., Hahn v. Dorsche, H.: Der Einfluß der Vagotomie auf die Glukosetoleranz sowie die Reaktionen von Plasmainsulin und exokriner Pankreasfunktion nach Glukosebelastung oder Nahrungsaufnahme bei Hunden. Acta Biol. Med. Ger.35, 1279–1291 (1976)
Garratt, J., Butterfield, W.J.H., Abrams, M.E., Sterky, G., Whichelow, M.J.: Effect of exercise on peripheral uptake of 131-I-insulin and glucose in non-diabetics. Metabolism21, 36–47 (1972)
Goldfine, I.D., Abraira, C., Gruenewald, D., Goldstein, M.S.: Plasma insulin levels during imaginary food ingestion under hypnosis. Proc. Soc. Exp. Biol. Med.133, 274–276 (1970)
Hommel, H., Fischer, U., Retzlaff, K., Knöfler, H.: The mechanism of insulin secretion after oral glucose administration. II. Reflex insulin secretion in conscious dogs bearing fistulas of the digestive tract by sham-feeding of glucose or tap water. Diabetologia8, 111–116 (1972)
Hommel, H., Fischer, U., Gottschling, H.-D., Bergos, O.V.: The mechanism of insulin secretion after oral glucose administration. VI. The influence of stomach and of small intestine (russ.). Physiol. J. SSSR (Setschenov)62, 1506–1513 (1976)
Horwitz, D.L., Starr, J.I., Mako, M.E., Blackard, W.G., Rubenstein, A.H.: Proinsulin, insulin and C-peptide concentrations in human portal and peripheral blood. J. Clin. Invest.55, 1278–1283 (1975)
Kaden, M., Curtin, R., Carey, L., Taylor, F., Field, J.B.: Evaluation of factors regulating hepatic extraction of insulin. Diabetes20, 341–342 (1971)
Karamanos, B., Butterfield, W.J.H., Asmal, A.C., Cox, B.D., Whichelow, M.J.: The pattern of the early insulin response to oral glucose. Postgrad. Med. J.47, 440–443 (1971)
Kobayashi, S., Fujita, T.: Fine structure of mammalian and avian pancreatic islets with special reference to D cells and nervous elements. Z. Zellforsch.100, 340–363 (1969)
Köhler, P.: Verbesserte Glukoseoxydasemethode zur Blutzuckerbestimmung im Routinebetrieb des klinischen Laboratoriums. Z. Gesamte Inn. Med.17, 674–676 (1962)
Kuzuya, T.: Regulation of insulin secretion by the central nervous system. II. The role of the hypothalamus and the pituitary gland upon insulin secretion. J. Jpn. Soc. Intern. Med.51, 65–74 (1962)
Louis-Sylvestre, J.: Preabsorptive insulin release and hypoglycemia in rats. Am. J. Physiol.230, 56–60 (1976)
London, E.S., Kotschneff, N.: Der Mechanismus der alimentären Hyperglykämie. I. Die Rolle der Zuckerresorption aus dem Darm und der Inkretion des Pankreas. Z. Gesamte Exp. Med.101, 767–775 (1937)
Malaisse-Lagae, F., Ravazzola, M., Robberecht, P., Vandermeers, A., Malaisse, W.J., Orci, L.: Exocrine pancreas: Evidence for topographic partition of secretory function. Science190, 795–797 (1975)
Reyes-Leal, B., Castro, A., Bernal, B., Guadiola, O.: Le role du duodenum dans l'insulino-sécretion. Sem. Hop. Paris49, 1611–1617 (1973)
Rubenstein, A.H., Zwi, S., Miller, K.: Insulin and the lung. Diabetologia4, 236–238 (1968)
Siegel, S.: Conditioning of insulin glycemia. J. Comp. Physiol. Psychol.75, 233–241 (1972)
Steffens, A.B., Mogenson, G.J., Stevenson, J.A.F.: Blood glucose, insulin, and free fatty acids after stimulation and lesions of the hypothalamus. Am. J. Physiol.222, 1446–1452 (1972)
Strubbe, J.H., Steffens, A.B.: Rapid insulin release after ingestion of a meal in the unanaesthetized rat. Am. J. Physiol.229, 1019–1022 (1975)
Toivola, P.T.K., Cale, C.C., Goodner, C.J., Werrbach, J.H.: Central alpha-adrenergic regulation of growth hormone and insulin. Hormones3, 193–213 (1972)
Vinik, A.J., Kalk, W.J., Keller, P., Beaumont, P., Jackson, W.P.U.: Overactivity of the entero-insulinar axis in maturity-onset diabetes. Lancet 1973II, 183–185
Waddell, W.R., Sussmann, K.E.: Plasma insulin after diversion of portal and pancreatic venous blood to vena cava. J. Appl. Physiol.22, 808–812 (1967)
Watari, N., Taukagoshi, N., Honma, Y.: The correlative light and electron microscopy of the islet of Langerhans in some lower vertebrates. Arch. Histol. Jpn.31, 371–392 (1970)
Woods, S.C., Porte jr., D.: Neural control of the endocrine pancreas. Physiol. Rev.54, 596–619 (1974)
Woods, S.C., Shogren, R.E.: Glycemic response following conditioning with different doses of insulin in rats. J. Comp. Physiol. Psychol.81, 220–225 (1972)
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Investigations supported by the research project “Diabetes mellitus and diseases of lipid metabolism” of the Ministry of Health of the GDR
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Hommel, H.H., Fischer, U. The mechanism of insulin secretion after oral glucose administration. Diabetologia 13, 269–272 (1977). https://doi.org/10.1007/BF01219711
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DOI: https://doi.org/10.1007/BF01219711