Summary
Compared with our previous report, a milder form of diabetic syndrome induced by diet in Egyptian sand rats is described. In sand rats fed vegetables for a prolonged period after capture, pancreatic insulin content was significantly increased. When fed chow, one-third of young animals developed hyperglycemia to a variable degree. Hyperinsulinemia was even more marked than in the previously reported group (Miki et al., 1966) and persisted even when the blood glucose returned to normal following fasting. Pancreatic insulin content was decreased in hyperglycemic sand rats. Insulin refractoriness of adipose tissue was discussed in relation to the pathogenesis.
Résumé
Nous avons induit par modification du régime chez le rat des sables égyptien un syndrome diabétique plus modéré que celui décrit dans la précédente communication (Miki et al., 1966). Maintenus à un régime végétal pendant une longue période après leur capture, la teneur en insuline du pancréas de ces animaux augmente de façon significative. Par contre, lorsqu'ils sont soumis au régime standard de laboratoire (granuléscomprimés) une hyperglycémie de degré variable s'installe chez environ un tiers des jeunes rats. L'hyperinsulinémie s'est révélée être encore plus élevée chez ces animaux que chez ceux décrits antérieurement et elle persiste même après un retour à la normale de la glycémie au cours du jeûne. Chez les rats hyperglycémiques, le contenu du pancréas en insuline diminue. Le rôle possible de la résistance du tissu adipeux à l'action de l'insuline dans la pathogénèse de ce syndrome est discuté.
Zusammenfassung
Eine mildere Form von diätinduziertem diabetischen Syndrom in der Ägyptischen Sandratte wird beschrieben. In Sandratten, die für längere Zeit nach der Gefangennahme mit Gemüse gefüttert worden waren, war der Pankreasinsulingehalt stark erhöht, der Blutzucker aber normal. Ein Drittel der jungen Tiere, hingegen, die mit Labor-Keks gefüttert wurden, entwickelte Hyperglykämie verschiedenen Grades. Hyperinsulinämie war sogar noch stärker ausgeprägt, als in der vorher beschriebenen Gruppe (Miki et al., 1966) und dauerte selbst dann an, wenn der Blutzucker durch Fasten auf normale Werte zurückgebracht wurde. Der Pankreasinsulingehalt hyperglykämischer Sandratten war gegenüber der Norm erniedrigt. Die Insulinempfindlichkeit des Fettgewebes wird im Zusammenhang mit der Pathogenese diskutiert.
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Supported in part by grants-in-aid from the United States Public Health Service T1-AM-5077-10, AM-09584-02, AM-09748-01 and by the John A. Hartford Foundation, New York, New York and the Adler Foundation, Inc., Rye, New York.
Paper I of this Series isMiki et al. 1966.
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Miki, E., Like, A.A., Steinke, J. et al. Diabetic syndrome in sand rats. Diabetologia 3, 135–139 (1967). https://doi.org/10.1007/BF01222190
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DOI: https://doi.org/10.1007/BF01222190