Summary
The key finding in our study is a diminished tolerance for glucose in the potentially diabetic vegetable-fed sand rat, induced or aggravated by brief periods of food deprivation. This “starvation diabetes” may represent an ideal experimental model for study of the mechanism involved in the development of diabetes in the chow-fed animal.
Résumé
L'observation principale que nous rapportons est celle d'une diminution de la tolérance au glucose chez le rat des sables potentiellement diabétique, même soumis à un régime consistant exclusivement en légumes. Cette intolérance est induite ou aggravée par des périodes même brèves de jeûne. Ce «diabète de la faim» pourrait bien s'avérer être un diabète expérimental idéal pour l'étude de la pathogénèse du diabète qu'on observe chez l'animal soumis à un régime normal, plus riche en calories.
Zusammenfassung
Das Hauptergebnis unserer Untersuchung ist die Beobachtung einer verminderten Toleranz für Glucose in der potentiell diabetischen Sandratte, selbst bei rein pflanzlicher Ernährung. Verursacht oder verschlimmert wurde dieser Zustand durch kurze Perioden von Nahrungsentzug. Dieser „Hungerdiabetes“ könnte ein ideales Versuchsmodell darstellen, und die Aufklärung des diabetogenen Mechanismus bei normaler Laboratoriumskost erleichtern.
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This work was supported by a grant from the United States Public Health Service (AM 10675-01).
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Brodoff, B.N., Penhos, J.C. & Levine, R. The effects of feeding and various hormones on the glucose tolerance of the sand rat (psammomys obesus). Diabetologia 3, 167–170 (1967). https://doi.org/10.1007/BF01222193
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DOI: https://doi.org/10.1007/BF01222193