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Low-dose cyclosporin A therapy in cadaver renal transplantation in children

  • Original Articles
  • Published:
Transplant International

Abstract

Fifty-one pediatric patients undergoing a first cadaveric kidney transplantation were followed for at least 2 years after grafting. They were divided into two groups: those treated with methylprednisolone plus azathioprine (AZA) and those treated with methylprednisolone plus low-dose cyclosporin A (CyA; median dose 109 mg/m2 per day ≙ 3.4 mg/kg per day after 1 year). The steroid dosage given was significantly lower in the second group. The 4-year graft survival rate was 68% for the AZA group and 78% for the CyA group. Renal function did not differ significantly in the two groups; after 1, 2, and 3 years, the median 24-h creatinine clearance was 79, 69, and 51 ml/min/1.73 m2, respectively, for the AZA group and 78, 63, and 68 ml/min/1.73 m2, respectively, for the CyA group. Linear growth was similar in the two groups. We conclude that in pediatric patients the results of low-dose CyA immunosuppression do not differ significantly from those obtained with AZA in terms of graft survival, renal function, or growth.

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Author information

Author notes

  1. H. Ruder

    Present address: Pädiatrische Nephrologie, Universitäts-Kinderklinik, Loschgestrasse 15, D-8520, Erlangen, Germany

Authors and Affiliations

  1. Division of Pediatric Nephrology, University Hospital, Im Neuenheimer Feld 150, D-6900, Heidelberg, Germany

    H. Ruder, J. Strehlau, F. Schaefer, D. E. Müller-Wiefel, K. E. Bonzel, O. Mehls & K. Schärer

  2. Division of Urology, University Hospital, Im Neuenheimer Feld 150, D-6900, Heidelberg, Germany

    K. Möhring & S. Pomer

  3. Clinic of Nephrology, Klinikum Mannheim, University of Heidelberg, D-6800, Mannheim, Germany

    N. Gretz

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  1. H. Ruder
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Cite this article

Ruder, H., Strehlau, J., Schaefer, F. et al. Low-dose cyclosporin A therapy in cadaver renal transplantation in children. Transplant Int 2, 203–208 (1989). https://doi.org/10.1007/BF02414535

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  • DOI: https://doi.org/10.1007/BF02414535

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