Abstract
A gas Chromatographic method for the detection of tetrodotoxin in autopsy material is described. The derivative (2-amino-6-hydroxymethyl-8-hydroxyquinazoline, C9-base), which was obtained from tetrodotoxin by alkali treatment, was finally detected by gas chromatography. The mass spectra of the trimethylsilylated (TMS) C9-base are presented together with the result of a gas Chromatographic investigation of 8 cases of fatal intoxication.
Zusammenfassung
Eine gaschromatographische Methode zum Nachweis von Tetrodotoxin im Obduktionsmaterial wird beschrieben. Das Derivat (2-Amino-6-hydroxymethyl-8-hydroxychinazolin, C9-Base), das sich durch die Einwirkung der Alkalilauge auf Tetrodotoxin gewinnen ließ, wurde schließlich durch Gaschromatographic nachgewiesen. Die Massenspektren der trimethylsilyerten C9-Base werden neben den Ergebnissen der gaschromatographischen Untersuchung von acht tödlichen Intoxikationsfällen angegeben.
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Suenaga, K., Kotoku, S. Detection of tetrodotoxin in autopsy material by gas chromatography. Arch. Toxicol. 44, 291–297 (1980). https://doi.org/10.1007/BF00278036
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DOI: https://doi.org/10.1007/BF00278036