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Toxicological evaluation of cyclosporin A

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Abstract

Toxicological studies in a variety of different animal species have shown that cyclosporin A (CS-A) is a unique immunosuppressant, since it does not cause myelotoxic, teratogenic, mutagenic, or carcinogenic effects. This is undoubtedly due to the fact that CS-A produces its immunosuppressive effects by a specific action on T lymphocytes rather than by a cytotoxic mechanism. The incidence of acute inflammatory lesions was also not significantly higher in treated animals than in controls. Clear-cut organ toxicity only occurred in rats and cynomolgus monkeys, where at high doses nephro- and hepatotoxicity were observed.

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Authors and Affiliations

  1. Preclinical Research, Toxicology, Sandoz Ltd., CH-4002, Basel, Switzerland

    B. Ryffel, P. Donatsch, M. Madörin, B. E. Matter, G. Rüttimann, H. Schön & J. Wilson

  2. Pharmaceutical Research and Development, Sandoz Inc., East Hanover, NJ, USA

    R. Stoll

Authors
  1. B. Ryffel
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  2. P. Donatsch
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  3. M. Madörin
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  4. B. E. Matter
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  5. G. Rüttimann
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  6. H. Schön
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  7. R. Stoll
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  8. J. Wilson
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Ryffel, B., Donatsch, P., Madörin, M. et al. Toxicological evaluation of cyclosporin A. Arch Toxicol 53, 107–141 (1983). https://doi.org/10.1007/BF00302721

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  • DOI: https://doi.org/10.1007/BF00302721

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