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The action of perseitol heptanitrate on the coronary circulation in dogs

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Summary

Perseitol heptanitrate, prepared by nitration of the 7 carbon heptanol, perseitol, extracted from the seed of the Mexican avocado, was compared with other organic nitrates in its action on the coronary circulation of dogs. When injected into the coronary circulation of isolated hearts perfused from a donor dog, or of hearts prepared in situ, its coronary dilator action was qualitatively similar to the effects of nitroglycerin, mannitol hexanitrate, and pentaerythrityl tetranitrate. Upon intravenous injection, the longer chain nitrates were from 8 to 15 times less active than nitroglycerin in their effects upon coronary flow and arterial pressure.

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Authors and Affiliations

  1. From the Departamento de Farmacologia, Instituto Nacional de Cardiologia, Mexico, D.F., Mexico

    Rafael Mendez & Jorge Aceves

Authors
  1. Rafael Mendez
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  2. Jorge Aceves
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Dedicated to Professor Otto Krayer on his 65th birthday.

With 4 Figures in the Text

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Mendez, R., Aceves, J. The action of perseitol heptanitrate on the coronary circulation in dogs. Naunyn - Schmiedebergs Arch 248, 343–350 (1964). https://doi.org/10.1007/BF00246351

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  • DOI: https://doi.org/10.1007/BF00246351

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