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Quantitative Bestimmung der Wirksamkeit von Hochdruckmittel-Kombinationen

Quantitative evaluation of combinations of antihypertensive agents

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Summary

A new method is described which permits the determination of the biometrically defined relative combined activity of drug combinations.

Combinations of substances with antihypertensive action were investigated on rats with experimental renal hypertension. The effects of the combinations α-methyldopa-guanacline and reserpine-guanacline were significantly more than additive, the effect of the combination α-methyldopa-reserpine was at most, additive.

Zusammenfassung

Es wird über eine Methode berichtet, die bei der Prüfung von Arzneimittelkombinationen die Bestimmung der biometrisch definierten relativen Kombinationswirksamkeit gestattet.

Untersucht wurden an Ratten mit experimentellem renalen Hochdruck Kombinationen von antihypertensiv wirksamen Stoffen. Die Kombinationen α-Methyldopa-Guanacline und Reserpin-Guanacline wirkten signifikant überadditiv, die Kombination α-Methyldopa-Reserpin allenfalls additiv.

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Literatur

  • Breuninger, H.: Methode zur unblutigen Messung des Blutdruckes an Kleintieren. Arzneimittel-Forsch. 6, 222 (1956).

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  • Finney, D. J.: Statistical method in biological assay. London: Griffin 1964.

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  • —— aus J. H. Burn, D. J. Finney, and L. G. Goodwin: Biological standardization. London: Oxford University Press 1952.

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  • Grollmann, A.: A simplified procedure for inducing chronic renal hypertension in the mammal. Proc. Soc. exp. Biol. (N.Y.) 57, 102 (1956).

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Authors and Affiliations

  1. Institut für Pharmakologie der Farbenfabriken Bayer AG, Wuppertal-Elberfeld

    K. Stoepel, H. Kaller & G. Kroneberg

Authors
  1. K. Stoepel
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  2. H. Kaller
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  3. G. Kroneberg
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Additional information

Herrn Professor Dr. L. Lendle zum 70. Geburtstag gewidmet.

Siehe kurze Mitteilung der Ergebnisse auf der 9. Frühjahrstagung der Deutschen pharmakologischen Gesellschaft, Mainz, 1968.

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Stoepel, K., Kaller, H. & Kroneberg, G. Quantitative Bestimmung der Wirksamkeit von Hochdruckmittel-Kombinationen. Naunyn-Schmiedebergs Arch. Pharmak. u. Exp. Path. 262, 189–196 (1969). https://doi.org/10.1007/BF00537659

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  • DOI: https://doi.org/10.1007/BF00537659

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