Abstract
The effects of pretreatments on behavioural responses to activation of 5-HT1C receptors bym-chlorophenylpiperazine (mCPP) were investigated. The hypo locomotor and anxiogenic effects ofmCPP (social interaction test) were influenced neither by previous housing (single versus grouped) nor by restraint (2 h, 24 h previously). In the absence ofmCPP, 24 h group housing led to decreased social interaction and the restraint procedure led to significant decreases of feeding and locomotion. The hypophagic effect ofmCPP was unaffected by previous restraint. However, chronic pretreatment withmCPP (2.5 mg/kg per day IP × 14) or with the antidepressant 5-HT reuptake inhibitor sertraline (5 mg/kg per day SC × 14) attenuated all three behaviours. The above findings are discussed with respect to published data on effects of pretreatments on responses to the activation of 5-HT1C receptors.
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Kennedy, A.J., Gibson, E.L., O'Connell, M.T. et al. Effects of housing, restraint and chronic treatments withmCPP and sertraline on behavioural responses tomCPP. Psychopharmacology 113, 262–268 (1993). https://doi.org/10.1007/BF02245708
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DOI: https://doi.org/10.1007/BF02245708