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Untersuchungen über die Stereotypien nach Amphetamin und Apomorphin sowie deren pharmakologische Beeinflussung

The influence of neuroleptic and thymoleptic drugs on stereotypies induced by amphetamine and apomorphine in mice and rats

  • Original Investigations
  • Animal Studies
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Abstract

The behaviour of mice after various doses of amphetamine or apomorphine which induce stereotypies is described in details. The induced stereotyped behaviour in mice appears more differentiated than that in rats. The amphetamine-syndrome in rats consists of an excitement phase followed by the stereotypy, whereas apomorphine elicits stereotyped behaviour directly after administration. Amphetamine-induced stereotyped behaviour is different from the apomorphine-induced stereotypy in several respects.

Neuroleptics inhibit the amphetamine (12.5 mg/kg s.c.) and apomorphine-(10 mg/kg s.c.) syndrome, while thymoleptics potentiate subeffective doses of amphetamine (5 mg/kg s.c.) and apomorphine (2 mg/kg s.c.). This is demonstrated with some neuroleptics of the phenothiazine-type, haloperidol, reserpine, and a group of thymoleptics. The method opens the possibility of differentiating within several groups of neuroleptics and within several groups of thymoleptics.

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  1. Pharmakologische Abteilung der Promonta GmbH, Hamburg

    H. G. Menge & U. Brand

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  1. H. G. Menge
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  2. U. Brand
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Wir danken Fräulein Christine Mosimann für die sorgfältige Durchführung der Tierexperimente.

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Menge, H.G., Brand, U. Untersuchungen über die Stereotypien nach Amphetamin und Apomorphin sowie deren pharmakologische Beeinflussung. Psychopharmacologia 21, 212–228 (1971). https://doi.org/10.1007/BF00403860

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  • DOI: https://doi.org/10.1007/BF00403860

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