Abstract
Rats were trained to choose between the arms of a T-maze apparatus according to whether they were injected i.p. with 0.1 Μmol/kg LSD or 0.9% saline. The LSD drug-state acquired the properties of a discriminative stimulus, possibly by producing interoceptive cues. Doses of 9.0 Μmol/kg psilocybin and 90 and 120 Μmol/kg mescaline produced cueing effects which were not significantly different from the cueing effect of LSD. However, d-amphetamine (14.8 and 29.6 Μmol/kg) did not appear to produce an LSD-like cue. These results suggest that LSD, mescaline and psilocybin, when administered in functionally equivalent doses, produce qualitatively similar interoceptive cues in the rat.
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Supported by grants from the American Medical Association Education and Research Foundation, and the National Institutes of Health, FR, 5697-01.
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Schechter, M.D., Rosecrans, J.A. Lysergic acid diethylamide (LSD) as a discriminative cue: Drugs with similar stimulus properties. Psychopharmacologia 26, 313–316 (1972). https://doi.org/10.1007/BF00422707
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DOI: https://doi.org/10.1007/BF00422707