Abstract
Rats sustained electrolytic lesions either in the medial septal (MS) or lateral septal (LS) area or they were sham-operated. They were tested in the straight alley with food reward on either continuous (CRF) or partial (PRF) reinforcement at one trial a day and were injected with either 5 mg/kg chlordiazepoxide HCl (CDP) or with saline before the daily trial throughout acquisition and extinction. The effects of the drug on resistance to extinction interacted with those of the LS lesion in ways which were consistent with the hypothesis that CDP acts via the lateral septal area if it is injected during acquisition on a PRF schedule. MS lesions produced only small changes in the effects of CDP. In general, CDP acted to reverse the effects produced by each lesion: Under those conditions in which MS lesions produced faster running speeds, CDP caused the lesioned animals to run slower; and under those conditions in which LS lesions produced slower running speeds, CDP caused the lesioned animals to run faster.
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References
Amsel A (1962) Frustrative nonreward in partial reinforcement and discrimination learning: Some recent history and a theoretical extension. Psychol Rev 69:306–328
Donovick PJ (1968) Effects of localized septal lesions on hippocampal EEG activity and behaviour in rats. J Comp Physiol Psychol 66:569–578
Elliott K, Whelan J (eds) (1978) Functions of the septo-hippocampal system. Ciba Foundation Symposium 58 (new series). Elsevier, Amsterdam
Feldon J, Gray JA (1979a) Effects of medial and lateral septal lesions on the partial reinforcement extinction effect at one trial a day. Q J Exp Psychol 31:653–674
Feldon J, Gray JA (1979b) Effects of medial and lateral septal lesions on the partial reinforcement extinction effect at short inter-trial intervals. Q J Exp Psychol 31:675–690
Feldon J, Gray JA (1981) The partial reinforcement extinction effect after treatment with chlordiazepoxide. Psychopharmacology 73:269–275
Feldon J, Guillamon A, Gray JA, de Wit H, McNaughton N (1979) Sodium amylobarbitone and responses to nonreward. Q J Exp Psychol 31:19–50
Graeff FG, Rawlins JNP (1980) Dorsal periaqueductal gray punishment, septal lesions and the mode of action of minor tranquillizers. Pharmacol Biochem Behav 12:41–45
Gray JA (1970) Sodium amobarbital, the hippocampal theta rhythm and the partial reinforcement effect. Psychol Rev 77:465–480
Gray JA (1977) Drug effects on fear and frustration: Possible limbic site of action of minor tranquillizers. In: Iversen LL, Iversen SD, Snyder SH (eds) Handbook of psychopharmacology, vol 8. Plenum Press, New York, pp 433–529
Gray JA (1981) The neuropsychology of anxiety: An enquiry into the functions of the septo-hippocampal system. Oxford University Press, Oxford (in press)
Gray JA, Araujo-Silva MT (1971) Joint effects of medial septal lesions and amylobarbitone injections on resistance to extinction in the rat. Psychopharmacologia 22:8–22
Gray JA, Feldon J, Rawlins JNP, Owen S, McNaughton N (1978) The role of the septo-hippocampal system and its noradrenergic afferents in behavioural responses to nonreward. In: Elliott K, Whelan J (eds) Functions of the septo-hippocampal system. Ciba Foundation Symposium 58 (new series). Elsevier, Amsterdam, pp 275–307
Gray JA, Quintao L, Araujo-Silva MT (1972) The partial reinforcement extinction effect in rats with medial septal lesions. Physiol Behav 8:491–496
Rawlins JNP, Feldon J, Gray JA (1979) Septo-hippocampal connections and the hippocampal theta rhythm. Exp Brain Res 37:49–63
Stumpf C (1965) Drug action on the electrical activity of the hippocampus. Int Rev Neurobiol 8:77–138
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Feldon, J., Gray, J.A. The partial reinforcement extinction effect: Influence of chlordiazepoxide in septal lesioned rats. Psychopharmacology 74, 280–289 (1981). https://doi.org/10.1007/BF00427111
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DOI: https://doi.org/10.1007/BF00427111